{
  "abstract": "Background: Tetrahydrothiophene (THT) and tert-butyl mercaptan (TBM) are sulfur-containing odorants used to detect natural gas leaks. Data on acute human exposure to these substances are limited.\n\nObjective: To describe the clinical and toxicological findings recorded following a reported release of a THT–TBM mixture.\n\nMaterials and Methods: This retrospective descriptive study reviewed records of 228 symptomatic patients with complete clinical files who were documented as present at the incident site after release of a 70% THT and 30% TBM mixture. The 5th Specialized Board of the Council of Forensic Medicine, Turkey, evaluated the records. Individual THT/TBM exposure measurements and odorant-specific biomarkers were unavailable.\n\nResults: The mean patient age was 32.94 ± 8.67 years; 85.5% were female. The most frequently reported symptoms were nausea (88.2%), dizziness (74.1%), shortness of breath (71.5%), drowsiness (54.0%), fatigue (51.3%), and headache (48.7%). Mydriasis was recorded in 29.8% of patients, and tachycardia in 32.0%. Arterial pH was below 7.35 in 56.1% of patients, and PaCO₂ was above 45 mmHg in 53.1%; oxygenation was generally preserved. Median lactate was 2.3 mmol/L (interquartile range: 1.2–4.5; >2.0 mmol/L in 60.1%). Median COHb was 3.4% (range: 0.1–11%; smoking status unrecorded). These rates represent symptomatic presenting patients, not all exposed individuals.\n\nConclusion: The reviewed records documented neurovegetative, respiratory, and ocular complaints. Acid-base and lactate abnormalities were nonspecific and cannot be causally linked to the event. No severe cardiopulmonary collapse or deaths were documented. Without long-term follow-up, delayed or persistent sequelae cannot be excluded.",
  "abstract_shown": true,
  "affiliations": [
    "5th Specialized Board, Council of Forensic Medicine, Istanbul, Turkey",
    "Head of 5th Specialized Board, Council of Forensic Medicine, Istanbul, Turkey",
    "Institute of Forensic Science and Legal Medicine, Istanbul University, Cerrahpasa, Istanbul, Turkey",
    "Tekirdag Branch, Council of Forensic Medicine, Tekirdag, Turkey"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Eda Yigit"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Faruk Asıcıoglu"
    },
    {
      "affs": [
        3
      ],
      "name": "Bayram Kaan Isıldak"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/apz1sd1amvh1w.bib",
  "cited_by": 0,
  "doi": "10.1016/j.toxrep.2026.102364",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13742497/",
  "id": "apz1sd1amvh1w",
  "issns": [
    "2214-7500"
  ],
  "landing_url": "https://doi.org/10.1016/j.toxrep.2026.102364",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
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      "openalex",
      "2711|Poisoning and overdose treatments"
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  "openalex": "W7224079002",
  "pdf_url": "https://www.sciencedirect.com/science/article/pii/S2214750026001666/pdf",
  "pmcid": "PMC13742497",
  "pmid": "42997831",
  "published": "2026-10-28",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/apz1sd1amvh1w.ris",
  "sources": [
    {
      "first_seen": "2026-11-10T12:23:19Z",
      "native_id": "PMC13742497",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.toxrep.2026.102364"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2711|Poisoning and overdose treatments",
      "subfield": "general"
    }
  ],
  "title": "Clinical and physiological findings in 228 patients evaluated following the accidental release of a natural gas odorant mixture containing tetrahydrothiophene and tert-butyl mercaptan",
  "title_text": "Clinical and physiological findings in 228 patients evaluated following the accidental release of a natural gas odorant mixture containing tetrahydrothiophene and tert-butyl mercaptan",
  "type": "peer-reviewed",
  "updated_at": "2026-11-10T12:23:19Z",
  "url": "https://research.draconitic.com/paper/apz1sd1amvh1w",
  "venue": "Toxicology Reports",
  "versions": []
}