{
  "abstract": "Area under the concentration–time curve (AUC)-guided dosing for vancomycin requires the measurement of both peak and trough concentrations. Recently, a novel population pharmacokinetic model (Bayesian-based, free-web application PAT version 4.0) was developed. The aim of the present study was to verify whether this optimized pharmacokinetic model improved the predictive accuracy of AUC calculated using trough-only data compared to data obtained using trough and peak sampling on Day 2. We conducted a single-center, cohort study to evaluate the agreement of AUC calculated using trough-only data compared to peak–trough sampling on Day 2, and to compare results obtained with the Yasuhara (previous) and Oda (updated) pharmacokinetic models. The proportion of trough/peak–trough AUC24–48 ratios within a 5% difference was significantly higher with the Oda model than with the Yasuhara model (75 vs. 58.3%, p = 0.034). Furthermore, multivariate logistic regression analysis showed that implementation of the Oda model was a significant factor associated with deviation of trough/peak–trough AUC24–48 within 5% (odds ratio 2.36, 95% confidence interval, 1.05–5.05, p = 0.027). The updated model offers enhanced predictive performance for AUC24–48 estimation using trough-only data. Further development of strategies to improve the predictive accuracy of AUC24–48 using trough-only data is warranted.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "name": "Takashi Niwa"
    },
    {
      "name": "Yuto Yamada"
    },
    {
      "name": "Kazuyuki Sumi"
    },
    {
      "name": "Shino Ando"
    },
    {
      "name": "Koshi Sakaida"
    },
    {
      "name": "Rina Takenaka"
    },
    {
      "name": "Akari Nishimura"
    },
    {
      "name": "Mizuki Yamaguchi"
    },
    {
      "name": "Ayasa Goto-Fujibayashi"
    },
    {
      "name": "Koki Hara"
    },
    {
      "name": "Manami Otsubo"
    },
    {
      "name": "Ryohei Miyashita"
    },
    {
      "name": "Akio Suzuki"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/aq23qzd79cw96.bib",
  "cited_by": 1,
  "doi": "10.1248/bpb.b26-00196",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/bpb/49/7/49_b26-00196/_article",
  "id": "aq23qzd79cw96",
  "issns": [
    "1347-5215",
    "0918-6158"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/bpb/49/7/49_b26-00196/_article",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/pharmacology-toxicology"
    ],
    [
      "openalex",
      "2736|Antibiotics Pharmacokinetics and Efficacy"
    ]
  ],
  "openalex": "W7168298731",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-15",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/aq23qzd79cw96.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:32Z",
      "native_id": "10.1248/bpb.b26-00196",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/bpb/49/7/49_b26-00196/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2736|Antibiotics Pharmacokinetics and Efficacy",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Comparison of Trough-Only and Peak–Trough Concentration Data for the Calculation of Vancomycin Area under the Concentration–Time Curve on Day 2 Using Previous and Updated Population Pharmacokinetic Models",
  "title_text": "Comparison of Trough-Only and Peak–Trough Concentration Data for the Calculation of Vancomycin Area under the Concentration–Time Curve on Day 2 Using Previous and Updated Population Pharmacokinetic Models",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:32Z",
  "url": "https://research.draconitic.com/paper/aq23qzd79cw96",
  "venue": "Biological and Pharmaceutical Bulletin",
  "versions": []
}