{
  "abstract": "Inflammation and the balance between antitumor surveillance and immunoregulatory mechanisms influence chemically induced skin tumor development. STAT6 is a central mediator of IL-4/IL-13 signaling, but its contribution to early skin papilloma development remains unclear. Here, we examined papilloma onset and burden, histopathological alterations, Treg accumulation, and CD8+ T-cell-associated responses in WT and STAT6-deficient mice subjected to a two-stage DMBA/TPA protocol. STAT6-/- mice developed papillomas significantly earlier and exhibited a markedly greater lesion burden than WT mice. This phenotype was associated with more prominent keratinization-related histopathological features, increased Foxp3+ Treg frequency and PD-1 expression in skin-draining lymph nodes, and a broader distribution of Foxp3+ cells within papillomas. STAT6 deficiency was also accompanied by attenuated CD8+IFN-γ+ responses in draining lymph nodes and reduced CD8+ cell infiltration within lesions. Collectively, these findings reveal a distinct immune profile associated with enhanced susceptibility to chemically induced skin papillomas and underscore the context-dependent role of STAT6 in cutaneous tumor immunity.",
  "abstract_shown": true,
  "affiliations": [
    "Unidad de Biomedicina (UBIMED), Facultad de Estudios Superiores-Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla 54090, Mexico.",
    "Carrera de Médico Cirujano, Facultad de Estudios Superiores-Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla 54090, Mexico.",
    "Neuropatología, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City 14269, Mexico."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Aranza Mejía-Muñoz"
    },
    {
      "affs": [
        0
      ],
      "name": "Tania Galindo-Santamaría"
    },
    {
      "affs": [
        0
      ],
      "name": "Valeria Moreno-Tovar"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Citlaltepetl Salinas-Lara"
    },
    {
      "affs": [
        2
      ],
      "name": "Carlos Sánchez-Garibay"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Rubén D Arroyo Olarte",
      "orcid": "0000-0002-8096-2423"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Sonia Leon-Cabrera",
      "orcid": "0000-0002-1661-5013"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/aq2cfq4v1dqem.bib",
  "cited_by": 0,
  "doi": "10.3390/biology15191747",
  "fulltext_url": "https://europepmc.org/articles/PMC13663411",
  "id": "aq2cfq4v1dqem",
  "issns": [
    "2079-7737"
  ],
  "landing_url": "https://europepmc.org/article/MED/42883420",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2403|T-cell and B-cell Immunology"
    ]
  ],
  "openalex": "W7216334146",
  "pdf_url": "https://europepmc.org/articles/PMC13663411?pdf=render",
  "pmcid": "PMC13663411",
  "pmid": "42883420",
  "published": "2026-10-02",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/aq2cfq4v1dqem.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:00Z",
      "native_id": "MED:42883420",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42883420"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|T-cell and B-cell Immunology",
      "subfield": "immunology"
    }
  ],
  "title": "STAT6 Deficiency Accelerates DMBA/TPA-Induced Skin Papilloma Development and Is Associated with Regulatory T-Cell Accumulation and Reduced CD8+IFN-γ+ Responses.",
  "title_text": "STAT6 Deficiency Accelerates DMBA/TPA-Induced Skin Papilloma Development and Is Associated with Regulatory T-Cell Accumulation and Reduced CD8+IFN-γ+ Responses.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:00Z",
  "url": "https://research.draconitic.com/paper/aq2cfq4v1dqem",
  "venue": "Biology",
  "versions": []
}