{
  "abstract": "Cellular senescence plays key roles in tissue repair, tumour suppression and ageing. Here we identify a rapid, transcription‑independent senescence response in skin following injury. Within minutes to hours after wounding, skin cells at the edge of injury display hallmark features of senescence. This response involves the utilization of pre‑existing Cdkn1a mRNA through the removal of nuclear export inhibitors, which enables Cdkn1a transcript translation and rapid p21 protein accumulation. These cells enter stable cell‑cycle arrest and secrete pro‑migratory and pro‑inflammatory factors that promote tissue repair, including re‑epithelialization. Experimental suppression of this rapid senescence, either genetically or pharmacologically, markedly delays wound closure, whereas inhibition during later phases of repair has no effect. Our findings establish rapid‑onset senescence as a mechanistic requirement for efficient tissue regeneration.",
  "abstract_shown": true,
  "affiliations": [
    "Austrian Cluster for Tissue Regeneration, Vienna, Austria",
    "Institute of Molecular Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria",
    "Ludwig Boltzmann Institute for Traumatology in AUVA Research Center, Vienna, Austria",
    "Ludwig Boltzmann Research Group Senescence and Healing of Wounds, Vienna, Austria",
    "Department of Physiology and Biomedical Engineering and Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA",
    "InLife Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Regenerative Biology Team, Olsztyn, Poland",
    "University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria",
    "Institut Hospitalo-Universitaire (IHU) RESPIRera and FHU OncoAge, CHU, Nice, France",
    "Université Côte d'Azur, Centre National de la Recherche Scientifique (CNRS) UMR7284, Institut National de la Santé et de la Recherche Médicale (INSERM) U1081, Adipo-Cible Research Study Group, Institute for Research on Cancer and Aging, Nice (IRCAN), Nice, France",
    "Kyiv School of Economics, Kyiv, Ukraine",
    "Research and Development University, Ivano-Frankivsk, Ukraine",
    "Department of Agricultural Sciences, University of Natural Resources and Life Sciences, Vienna, Austria",
    "Institute of In Vivo and In Vitro Models, University of Veterinary Medicine Vienna, Vienna, Austria",
    "Center for Biomedical Research and Translational Surgery, Medical University of Vienna, Vienna, Austria",
    "New Cornerstone Science Laboratory, State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China",
    "Austrian Cluster for Tissue Regeneration, Vienna, Austria. mikolaj.ogrodnik@lbg.ac.at",
    "Ludwig Boltzmann Institute for Traumatology in AUVA Research Center, Vienna, Austria. mikolaj.ogrodnik@lbg.ac.at",
    "Ludwig Boltzmann Research Group Senescence and Healing of Wounds, Vienna, Austria. mikolaj.ogrodnik@lbg.ac.at"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 35,
  "authors": [
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Karla Valdivieso",
      "orcid": "0000-0002-8058-5453"
    },
    {
      "affs": [
        0,
        2,
        3
      ],
      "name": "Tomaz Rozmaric",
      "orcid": "0000-0003-1744-6538"
    },
    {
      "affs": [
        4
      ],
      "name": "Stella G. Victorelli",
      "orcid": "0000-0001-5573-8019"
    },
    {
      "affs": [
        0,
        2,
        3
      ],
      "name": "Vaibhav Jadhav"
    },
    {
      "affs": [
        0,
        2,
        3
      ],
      "name": "Nadja Ring",
      "orcid": "0000-0001-6006-6544"
    },
    {
      "affs": [
        5
      ],
      "name": "Sylwia Machcińska-Zielińska",
      "orcid": "0000-0003-3892-4519"
    },
    {
      "affs": [
        0,
        2,
        6
      ],
      "name": "Barbara Schädl",
      "orcid": "0000-0002-6712-6279"
    },
    {
      "affs": [
        0,
        2,
        3
      ],
      "name": "Helene Dworak"
    },
    {
      "affs": [
        0,
        2,
        3
      ],
      "name": "Eirini Klinaki",
      "orcid": "0000-0002-3497-8926"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Ines Fischer"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Agnieszka Gadecka"
    },
    {
      "affs": [
        7,
        8
      ],
      "name": "Iryna Moskalevska",
      "orcid": "0009-0002-5583-1672"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Sara Kostrebic"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Michaela Kienberger"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Edyta Marzec"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Christina Efraimoglou"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Alessia Zanchetta"
    },
    {
      "affs": [
        7,
        8
      ],
      "name": "Julien Cherfils‐Vicini",
      "orcid": "0000-0001-7813-1527"
    },
    {
      "affs": [
        9,
        3,
        10
      ],
      "name": "Oleh V. Lushchak",
      "orcid": "0000-0002-4627-1987"
    },
    {
      "affs": [
        0,
        2,
        6
      ],
      "name": "Andreas Löscher"
    },
    {
      "affs": [
        11,
        12
      ],
      "name": "Thomas Kolbe",
      "orcid": "0000-0003-2974-8066"
    },
    {
      "affs": [
        12
      ],
      "name": "Maik Dahlhoff",
      "orcid": "0000-0001-9189-7631"
    },
    {
      "affs": [
        4
      ],
      "name": "Nicholas Pirius"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Aniko Gutasi"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Sarolta Takacs"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "James Ferguson",
      "orcid": "0000-0002-5646-3851"
    },
    {
      "affs": [
        13
      ],
      "name": "Bruno K. Podesser"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Paul Slezak",
      "orcid": "0000-0002-1000-4393"
    },
    {
      "affs": [
        4
      ],
      "name": "David G. Monroe",
      "orcid": "0000-0002-4818-0114"
    },
    {
      "affs": [
        14
      ],
      "name": "Bin Zhou",
      "orcid": "0000-0001-5278-5522"
    },
    {
      "affs": [
        4
      ],
      "name": "Sundeep Khosla",
      "orcid": "0000-0002-2936-4372"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Johannes Grillari",
      "orcid": "0000-0001-5474-6332"
    },
    {
      "affs": [
        0,
        2,
        3
      ],
      "name": "Heinz R. Redl",
      "orcid": "0000-0003-1654-462X"
    },
    {
      "affs": [
        4
      ],
      "name": "Diana Jurk",
      "orcid": "0000-0003-4486-0857"
    },
    {
      "affs": [
        15,
        16,
        17
      ],
      "name": "Mikolaj B. Ogrodnik",
      "orcid": "0000-0003-3137-2037"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/aq6dymvjnp1ks.bib",
  "cited_by": 18,
  "doi": "10.1038/s41556-026-01948-2",
  "fulltext_url": null,
  "id": "aq6dymvjnp1ks",
  "issns": [
    "1465-7392",
    "1476-4679"
  ],
  "landing_url": "https://doi.org/10.1038/s41556-026-01948-2",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1307|Telomeres, Telomerase, and Senescence"
    ],
    [
      "openalex",
      "2737|Telomeres, Telomerase, and Senescence"
    ]
  ],
  "openalex": "W4393240811",
  "pdf_url": null,
  "pmcid": "PMC13279267",
  "pmid": "42209725",
  "published": "2026-05-28",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/aq6dymvjnp1ks.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:26:54Z",
      "native_id": "W4393240811",
      "source": "openalex",
      "url": "https://doi.org/10.1038/s41556-026-01948-2"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1307|Telomeres, Telomerase, and Senescence",
      "subfield": "cell-biology"
    },
    {
      "field": "medicine",
      "origin": "openalex:2737|Telomeres, Telomerase, and Senescence",
      "subfield": "physiology"
    }
  ],
  "title": "Transcription-independent induction of rapid-onset senescence is integral to healing",
  "title_text": "Transcription-independent induction of rapid-onset senescence is integral to healing",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:05Z",
  "url": "https://research.draconitic.com/paper/aq6dymvjnp1ks",
  "venue": "Nature Cell Biology",
  "versions": []
}