{
  "abstract": "Eosinophils are multifunctional granulocytes involved in immune regulation, metabolism and tissue repair; however, the extent of their heterogeneity across tissues and the principles governing their specialization are not well defined. Here, we present a single-cell transcriptomic and proteomic atlas of mouse eosinophils spanning immune, barrier and metabolic sites. By integrating transcriptional profiling, high-dimensional surface proteomics and in vivo fate mapping, we show that eosinophil identity is shaped by both tissue-derived cues and the duration of local residency. Long-lived eosinophils in the small intestine diversify into transcriptionally and phenotypically distinct subsets, whereas short-lived and intermediate-lived populations in the lungs and colon, respectively, remain comparatively uniform. We identify trajectory-associated surface markers that stratify eosinophil maturation from bone-marrow progenitors to long-term tissue-resident subsets. This atlas establishes a unified framework in which tissue-specific residency time drives eosinophil maturation and diversification, providing a molecular toolkit for resolving eosinophil states in health and disease.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 17,
  "authors": [
    {
      "name": "Yanan Hu"
    },
    {
      "name": "Lianfu Wu"
    },
    {
      "name": "Sihao Qu"
    },
    {
      "name": "Wan Ting Kong"
    },
    {
      "name": "Xiaotong Yu"
    },
    {
      "name": "Jiaqian Xu"
    },
    {
      "name": "Ziyi Xu"
    },
    {
      "name": "Jialing He"
    },
    {
      "name": "Chong Wang"
    },
    {
      "name": "Zhaoyuan Liu"
    },
    {
      "name": "Liming Lu"
    },
    {
      "name": "Lai Guan Ng"
    },
    {
      "name": "Camille Blériot"
    },
    {
      "name": "Bing Su"
    },
    {
      "name": "Florent Ginhoux"
    },
    {
      "name": "Ziyi Li"
    },
    {
      "name": "Svetoslav Chakarov"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/aqaqskvq40qks.bib",
  "cited_by": 15,
  "doi": "10.1038/s41590-025-02382-6",
  "fulltext_url": null,
  "id": "aqaqskvq40qks",
  "issns": [
    "1529-2908",
    "1529-2916"
  ],
  "landing_url": "https://hal.science/hal-05762940v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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      "0.sdv"
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      "openalex",
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  "openalex": "W7119465919",
  "pdf_url": "https://hal.science/hal-05762940/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/aqaqskvq40qks.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:01Z",
      "native_id": "hal-05762940",
      "source": "hal",
      "url": "https://hal.science/hal-05762940v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "hal:2.sdv.bbm.gtp",
      "subfield": "proteomics-metabolomics"
    },
    {
      "field": "biology",
      "origin": "hal:1.sdv.bc",
      "subfield": "cell-biology"
    },
    {
      "field": "biology",
      "origin": "hal:1.sdv.imm",
      "subfield": "immunology"
    }
  ],
  "title": "Temporal and spatial atlas of eosinophil specialization across tissues",
  "title_text": "Temporal and spatial atlas of eosinophil specialization across tissues",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:01Z",
  "url": "https://research.draconitic.com/paper/aqaqskvq40qks",
  "venue": "Nature Immunology",
  "versions": []
}