{
  "abstract": "Lung cancer remains one of the most prevalent and lethal malignancies worldwide, resulting in approximately 1.5 million deaths annually. Currently, more than 75% of cases are diagnosed at an advanced stage due to the lack of effective early detection methods. Although several conventional diagnostic techniques are available, many exhibits limited sensitivity for early-stage detection and are often associated with high costs and invasiveness. Therefore, there is an urgent need for more accurate, cost-effective, and rapid approaches for early screening. Numerous lung cancer-associated non-coding RNAs (ncRNAs) have been extensively investigated as promising biomarkers for diagnosis, prognosis, and therapeutic monitoring. To leverage these biomarkers, various nanomaterial-enhanced biosensors—utilizing electrochemical, optical, and electromechanical platforms—have been developed for the rapid and selective detection of ncRNAs. This review provides a comprehensive overview of recent advances in nanobiosensor technologies for detecting lung cancer-associated ncRNAs, highlighting their substantial diagnostic potential while critically addressing the technical bottlenecks, reproducibility challenges, and regulatory hurdles that must be overcome for their successful clinical translation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biology, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran",
    "Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran",
    "Student Research Committee, Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran",
    "Department of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran",
    "Medical Cellular and Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran",
    "Behbahan Faculty of Medical Sciences, Behbahan, Iran",
    "Abadan University of Medical Sciences, Abadan, Iran",
    "Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran",
    "Department of Clinical Biochemistry, Research Center for Environmental Contaminants (RCEC), Abadan University of Medical Sciences, Abadan, Iran",
    "Department of Nursing, Malayer School of Medical Sciences, Hamadan University of Medical Sciences, Hamadan, Iran",
    "Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran",
    "Department of Molecular Medicine, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Sina Taghvimi"
    },
    {
      "affs": [
        1
      ],
      "name": "Zoleikha Asadi"
    },
    {
      "affs": [
        2
      ],
      "name": "Sajad Ehtiati"
    },
    {
      "affs": [
        3
      ],
      "name": "Mahzad Nikbakhtrad"
    },
    {
      "affs": [
        1,
        4
      ],
      "name": "Zeinab Chaharlashkar"
    },
    {
      "affs": [
        5
      ],
      "name": "Fereshteh Rahdan"
    },
    {
      "affs": [
        2
      ],
      "name": "Seyyed Hossein Khatami"
    },
    {
      "affs": [
        6
      ],
      "name": "Seyed Mohammad Salehi Behbahani"
    },
    {
      "affs": [
        6
      ],
      "name": "Hamidreza Zaheri"
    },
    {
      "affs": [
        7
      ],
      "name": "Ahmad Movahedpour",
      "orcid": "0000-0002-0576-4435"
    },
    {
      "affs": [
        8,
        9
      ],
      "name": "Hassan Ghasemi"
    },
    {
      "affs": [
        10,
        11
      ],
      "name": "Elahe Soltani Fard"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/aqbb5dwy6y7nv.bib",
  "cited_by": 0,
  "doi": "10.1186/s12935-026-04435-8",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13729393/",
  "id": "aqbb5dwy6y7nv",
  "issns": [
    "1475-2867"
  ],
  "landing_url": "https://doi.org/10.1186/s12935-026-04435-8",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "1312|Advanced biosensing and bioanalysis techniques"
    ]
  ],
  "openalex": "W7196956357",
  "pdf_url": null,
  "pmcid": "PMC13729393",
  "pmid": "42977917",
  "published": "2026-08-06",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/aqbb5dwy6y7nv.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:22:09Z",
      "native_id": "PMC13729393",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12935-026-04435-8"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Advanced biosensing and bioanalysis techniques",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Biosensors as transformative tools for detection of lung cancer based on non-coding RNA",
  "title_text": "Biosensors as transformative tools for detection of lung cancer based on non-coding RNA",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:09Z",
  "url": "https://research.draconitic.com/paper/aqbb5dwy6y7nv",
  "venue": "Cancer Cell International",
  "versions": []
}