{
  "abstract": "Adeno-associated virus (AAV) vectors have significantly advanced in vivo gene therapy for monogenic diseases. Humoral immunity to AAVs represents a major challenge toward the application of this gene transfer modality in the larger population. Pre-existing neutralizing antibodies (Nabs) to AAV capsids reduce the number of patients eligible for treatment, while post-treatment humoral immunity prevents vector re-administration. Addressing this challenge remains a critical need in the field. In this issue of Molecular Therapy, Doshi et al.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "name": "Hanadi Saliba"
    },
    {
      "name": "David Alexandre Gross"
    },
    {
      "name": "Giuseppe Ronzitti"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/aqrredj1cep1b.bib",
  "cited_by": 0,
  "doi": "10.1016/j.ymthe.2025.06.007",
  "fulltext_url": null,
  "id": "aqrredj1cep1b",
  "issns": [
    "1525-0016",
    "1525-0024"
  ],
  "landing_url": "https://hal.science/hal-05769992v1",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "1311|Virus-based gene therapy research"
    ]
  ],
  "openalex": "W4411515787",
  "pdf_url": "https://www.cell.com/molecular-therapy-family/molecular-therapy/pdf/S1525-0016(25)00458-7.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-29",
  "publisher": "Cell Press",
  "ris": "https://research.draconitic.com/paper/aqrredj1cep1b.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:43Z",
      "native_id": "hal-05769992",
      "source": "hal",
      "url": "https://hal.science/hal-05769992v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|Virus-based gene therapy research",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Harnessing B19-directed CAR T cells for AAV vector administration in seropositive patients: The importance of the niche",
  "title_text": "Harnessing B19-directed CAR T cells for AAV vector administration in seropositive patients: The importance of the niche",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:43Z",
  "url": "https://research.draconitic.com/paper/aqrredj1cep1b",
  "venue": "Molecular Therapy",
  "versions": []
}