{
  "abstract": "Introduction: This study aimed to investigate the phytochemical composition and multifunctional therapeutic potential of a hydroethanolic extract of Matricaria chamomilla L. collected from the semi-arid region of Algeria. The research focused on evaluating its antioxidant, antimicrobial, antidiabetic, antiinflammatory, neuroprotective, and potential anticancer activities. Methods: Total polyphenol and flavonoid contents were determined using spectrophotometric methods. The phytochemical profile was characterized by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS). Antioxidant activity was assessed using DPPH and galvinoxyl radical scavenging assays. Antimicrobial activity was evaluated against bacterial and fungal strains using inhibition zone measurements. Enzyme inhibitory activities against α-amylase, acetylcholinesterase, and butyrylcholinesterase were investigated in vitro. Anti-inflammatory activity was evaluated through protein denaturation inhibition and carrageenan-induced paw edema assays. Molecular docking studies were performed to assess the interactions of identified compounds with breast cancer targets ERα and HER2.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "name": "Abderrazek Ferhat"
    },
    {
      "name": "Mohammed Messaoudi"
    },
    {
      "name": "Khalil Guelifet"
    },
    {
      "name": "Ilham Ben Amor"
    },
    {
      "name": "Wafa Zahnit"
    },
    {
      "name": "Khadra Afaf Bendrihem"
    },
    {
      "name": "Azzeddine Zeraib"
    },
    {
      "name": "Hamza Ouakouak"
    },
    {
      "name": "Mokhtar Benmohamed"
    },
    {
      "name": "Mohamed Amine Ferhat"
    },
    {
      "name": "Imane Larkem"
    },
    {
      "name": "Huda Alsaeedi"
    },
    {
      "name": "Aftab Aslam Parwaz Khan"
    },
    {
      "name": "Mikhael Bechelany"
    },
    {
      "name": "Furong Tian"
    },
    {
      "name": "Ahmed Barhoum"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/aqx6ezdjw6401.bib",
  "cited_by": 1,
  "doi": "10.3389/fnut.2026.1852820",
  "fulltext_url": null,
  "id": "aqx6ezdjw6401",
  "issns": [
    "2296-861X"
  ],
  "landing_url": "https://hal.umontpellier.fr/hal-05770502v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
    [
      "openalex",
      "1110|Medicinal Plant Research"
    ]
  ],
  "openalex": "W7165117091",
  "pdf_url": "https://hal.umontpellier.fr/hal-05770502/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-06-18",
  "publisher": "Frontiers Media S.A.",
  "ris": "https://research.draconitic.com/paper/aqx6ezdjw6401.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:43Z",
      "native_id": "hal-05770502",
      "source": "hal",
      "url": "https://hal.umontpellier.fr/hal-05770502v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1110|Medicinal Plant Research",
      "subfield": "plant-biology"
    }
  ],
  "title": "Chemical profiling and in silico evaluation of a Matricaria chamomilla L. extract: exploring its antioxidant, antibacterial, antidiabetic, anti-inflammatory, and anticholinergic activities",
  "title_text": "Chemical profiling and in silico evaluation of a Matricaria chamomilla L. extract: exploring its antioxidant, antibacterial, antidiabetic, anti-inflammatory, and anticholinergic activities",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:43Z",
  "url": "https://research.draconitic.com/paper/aqx6ezdjw6401",
  "venue": "Frontiers in Nutrition",
  "versions": []
}