{
  "abstract": "Scutellaria baicalensis root is widely used in traditional medicine and functional foods, but information on its long-term toxicity remains limited. This study evaluated the acute and 26-week repeated-dose oral toxicity of S. baicalensis root extract (SBE) in male and female Sprague-Dawley rats under Good Laboratory Practice conditions. In the acute study, SBE was administered once at 2500 or 5000 mg/kg, followed by 14 days of observation. In the repeated-dose study, SBE was administered at 500, 1000, or 2000 mg/kg/day for 26 weeks, followed by a 4-week recovery period. No mortality occurred in either study. Acute administration caused only transient, non-adverse clinical signs, and the minimum lethal dose was >5000 mg/kg. Repeated administration at 2000 mg/kg/day increased relative liver weight and urinary ketone grades in both sexes, while absolute liver weight and serum triglycerides increased in females. These findings were considered treatment-related but non-adverse, without corroborating clinical, serum biochemical, or histopathological evidence of organ injury. The no-observed-effect level and no-observed-adverse-effect level were 1000 and 2000 mg/kg/day, respectively, and no target organ of toxicity was identified. These findings provide preclinical safety information for acute and long-term oral exposure to SBE.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jungbin Song",
      "orcid": "0000-0002-3587-9276"
    },
    {
      "affs": [
        0
      ],
      "name": "Hocheol Kim"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/aqz86vwamyjzp.bib",
  "cited_by": 0,
  "doi": "10.3390/toxics14100919",
  "fulltext_url": "https://europepmc.org/articles/PMC13709419",
  "id": "aqz86vwamyjzp",
  "issns": [
    "2305-6304"
  ],
  "landing_url": "https://europepmc.org/article/MED/42931707",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2736|Flavonoids in Medical Research"
    ]
  ],
  "openalex": "W7222968966",
  "pdf_url": "https://europepmc.org/articles/PMC13709419?pdf=render",
  "pmcid": "PMC13709419",
  "pmid": "42931707",
  "published": "2026-10-17",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/aqz86vwamyjzp.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:01Z",
      "native_id": "MED:42931707",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42931707"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2736|Flavonoids in Medical Research",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Safety Evaluation of Scutellaria baicalensis: Acute and 26-Week Repeated-Dose Oral Toxicity Studies in Rats.",
  "title_text": "Safety Evaluation of Scutellaria baicalensis: Acute and 26-Week Repeated-Dose Oral Toxicity Studies in Rats.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:01Z",
  "url": "https://research.draconitic.com/paper/aqz86vwamyjzp",
  "venue": "Toxics",
  "versions": []
}