{
  "abstract": "Background\n\nThe main features of minimal change disease (MCD) and focal segmental glomerulosclerosis associated with solid cancer [paraneoplastic podocytopathy with nephrotic syndrome (PPNS)] remain poorly described.Methods\n\nIn this French retrospective study, we followed up patients with PPNS and compared them to a control group with idiopathic nephrotic syndrome (INS). Demographic, clinical, laboratory, and pathological data were collected for both groups. Expression of C-Maf inducing protein (CMIP) was studied on kidney biopsies and tumor samples from PPNS and controls (patients with INS or cancer without nephrotic syndrome).Results\n\nTwenty-one PPNS patients (mean age 68 years, 76% men, 76% MCD) were identified. Baseline biological characteristics in PPNS (median urinary protein to creatinine ratio 0.87 g/mmol, albuminemia 15 g/l, and glomerular filtration rate 48 ml/min/1.73 m²) and INS (0.90 g/mmol, 15.3 g/l, and 60 ml/min/1.73 m², respectively) patients were similar. Complete remission of nephrotic syndrome occurred less frequently in PPNS than in INS (25% vs 74%, P = .008).CMIP was highly detected on podocytes from PPNS and INS, and in tumors from PPNS (13/13 samples, either in tumor cells and/or in lymphocytic infiltrates), but its expression was scarce in tumors not associated with nephrotic syndrome. Immunofluorescence analysis revealed that CMIP overexpression was confined to a CD4⁺ FOXP3⁻PD1⁻ T-cell subpopulation.Conclusions\n\nInitial presentation of PPNS is similar to that of INS but complete remission is less frequent. The tight association between nephrotic syndrome and CMIP expression in tumor cells suggests that CMIP might participate in this paraneoplastic syndrome.",
  "abstract_shown": true,
  "affiliations": [
    "Service de Physiologie-Explorations Fonctionnelles, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France.",
    "Université Paris-Est Créteil, INSERM U955, Institut Mondor de Recherche Biomédicale, Créteil, France.",
    "Service Néphrologie et Transplantation, Hôpitaux Universitaires Henri Mondor, Centre de Référence Maladies rares « Syndrome Néphrotique Idiopathique », Assistance Publique-Hôpitaux de Paris, Créteil, France.",
    "Sorbonne Université, INSERM U1155, Hôpital Tenon-Bâtiment Recherche, Paris, France.",
    "Service d'Anatomie et cytologie pathologiques, Hôpital Tenon, Assistance Publique - Hôpitaux de Paris, Paris, France.",
    "Service de Néphrologie, CHU Amiens Picardie (site Sud), Amiens, France.",
    "Service de Néphrologie, CHU Pontchaillou, Université de Rennes, Rennes, France.",
    "Service de Néphrologie et Transplantation, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France.",
    "Service de Néphrologie et Transplantation rénale, Centre Hospitalier Régional Universitaire de Lille, Lille, France.",
    "Service de Médecine Interne, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France.",
    "Service de Néphrologie, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France.",
    "Service de Néphrologie, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, Le Kremlin-Bicêtre, France.",
    "Université Paris Saclay, INSERM U1184, Le Kremlin-Bicêtre, France.",
    "Service de Néphrologie, Hôpitaux universitaires de Genève, Genève, Switzerland.",
    "Service de Néphrologie, Hôpital Foch, Suresnes, France.",
    "Service de Néphrologie et Dialyse, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Paris, France."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Arthur Michon Colin",
      "orcid": "0000-0002-8678-3733"
    },
    {
      "affs": [
        1
      ],
      "name": "Shao-Yu Zhang"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Vincent Audard"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "David Buob"
    },
    {
      "affs": [
        5
      ],
      "name": "Dimitri Titeca-Beauport",
      "orcid": "0000-0003-2514-4193"
    },
    {
      "affs": [
        6
      ],
      "name": "Henri Brenier"
    },
    {
      "affs": [
        7
      ],
      "name": "Evangeline Pillebout"
    },
    {
      "affs": [
        8
      ],
      "name": "Céline Lebas"
    },
    {
      "affs": [
        2
      ],
      "name": "Nizar Joher"
    },
    {
      "affs": [
        9
      ],
      "name": "Damien Sene"
    },
    {
      "affs": [
        10
      ],
      "name": "Alexandre Karras"
    },
    {
      "affs": [
        11,
        12
      ],
      "name": "Mohamad Zaidan"
    },
    {
      "affs": [
        13
      ],
      "name": "Sophie De Seigneux",
      "orcid": "0000-0002-2359-9621"
    },
    {
      "affs": [
        14
      ],
      "name": "Arwa Jalal Eddine"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Dil Sahali"
    },
    {
      "affs": [
        3,
        15
      ],
      "name": "Jean-Jacques Boffa"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ar2bt1tqegndm.bib",
  "cited_by": 0,
  "doi": "10.1093/ckj/sfag370",
  "fulltext_url": "https://europepmc.org/articles/PMC13748979",
  "id": "ar2bt1tqegndm",
  "issns": [
    "2048-8505",
    "2048-8513"
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  "landing_url": "https://europepmc.org/article/MED/43011595",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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  "pdf_url": "https://europepmc.org/articles/PMC13748979?pdf=render",
  "pmcid": "PMC13748979",
  "pmid": "43011595",
  "published": "2026-10-15",
  "publisher": "Oxford University Press",
  "ris": "https://research.draconitic.com/paper/ar2bt1tqegndm.ris",
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      "first_seen": "2026-11-12T15:25:13Z",
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  ],
  "title": "Paraneoplastic podocytopathies with nephrotic syndrome in solid cancers with C-Maf inducing protein expression.",
  "title_text": "Paraneoplastic podocytopathies with nephrotic syndrome in solid cancers with C-Maf inducing protein expression.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-13T15:20:22Z",
  "url": "https://research.draconitic.com/paper/ar2bt1tqegndm",
  "venue": "Clinical kidney journal",
  "versions": []
}