{
  "abstract": "Background: Aging is associated with sarcopenia, chronic low-grade inflammation, impaired functional capacity, and reduced respiratory muscle strength. Resistance training is recognized as an effective intervention to attenuate these age-related alterations; however, its effects on respiratory function and anti-aging biomarkers such as Klotho remain incompletely understood. Methods: In this randomized controlled trial, 60 community-dwelling older adults (60-75 years) were randomly allocated to a control group (n = 30) or a resistance training group (n = 30). Participants in the intervention group completed a supervised 12-week resistance training program (three sessions/week). Assessments performed before and after the intervention included anthropometry, body composition, respiratory muscle strength (maximal inspiratory and expiratory pressures), handgrip strength, 1 min sit-to-stand test, oxygen saturation, plasma levels of IL-6, IL-10, TNF-α, Klotho, and hematological parameters. Results: The resistance training group presented significantly increased maximal inspiratory and expiratory pressures, handgrip strength, and 1 min sit-to-stand performance while attenuating exercise-induced oxygen desaturation. The intervention also reduced plasma IL-6 concentrations and markedly increased circulating IL-10 and Klotho levels, indicating a favorable anti-inflammatory and anti-aging response. No significant changes were observed in systemic hematological parameters, whereas anthropometric adaptations were modest. Conclusions: Twelve weeks of resistance training significantly improved respiratory muscle strength and systemic inflammatory status in older adults. The concomitant increase in circulating Klotho suggests that resistance training may promote biological mechanisms associated with healthy aging, supporting its implementation as a non-pharmacological strategy to preserve functional independence and respiratory health in the elderly.",
  "abstract_shown": true,
  "affiliations": [
    "Laboratory of Pulmonary and Exercise Immunology, Evangelical University of Goias (UniEvangélica), Avenida Universitária Km 3,5, Anápolis 75083-515, GO, Brazil.",
    "Faculty of Health Sciences, Universidad Autônoma de Chile, Providencia, Santiago 7500912, Chile.",
    "Postgraduate Program in Health Science, Santo Amaro University (UNISA), São Paulo 04829-300, SP, Brazil.",
    "Department of Otorhinolaryngology-Head and Neck Surgery, Federal University of Sao Paulo (UNIFESP), Rua Pedro de Toledo 947, São Paulo 04038-032, SP, Brazil.",
    "Laboratory of Pulmonary and Exercise Immunology, Federal University of Sao Paulo (UNIFESP), Rua Talim 330, São José dos Campos 12231-280, SP, Brazil.",
    "Clinic of Pneumology, Medical Center, University of Freiburg, 79106 Freiburg im Breisgau, Germany.",
    "Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), Rua Taguatinga, Anápolis 75064-420, GO, Brazil."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Naiara Nadia Moreira-Silva"
    },
    {
      "affs": [
        0
      ],
      "name": "Meiry Souza Moura-Maia"
    },
    {
      "affs": [
        0
      ],
      "name": "Anamei Silva-Reis",
      "orcid": "0000-0002-4446-4320"
    },
    {
      "affs": [
        0
      ],
      "name": "Katielle Rodrigues Silva-Cardoso"
    },
    {
      "affs": [
        0
      ],
      "name": "Elano Silva-Sousa"
    },
    {
      "affs": [
        0
      ],
      "name": "Matheus Carrijo-Nascimento",
      "orcid": "0009-0009-3619-367X"
    },
    {
      "affs": [
        0
      ],
      "name": "Gustavo Paixão-Santos",
      "orcid": "0009-0000-2995-0550"
    },
    {
      "affs": [
        0
      ],
      "name": "Raianne Veiga-Celestino",
      "orcid": "0009-0003-8614-5904"
    },
    {
      "affs": [
        0
      ],
      "name": "Rosa Helena Ramos Paula-Vieira",
      "orcid": "0009-0008-6523-5421"
    },
    {
      "affs": [
        1
      ],
      "name": "Gaspar R Chiappa",
      "orcid": "0000-0002-0440-8404"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Andre Luis Lacerda Bachi",
      "orcid": "0000-0001-8266-1416"
    },
    {
      "affs": [
        4
      ],
      "name": "Regiane Albertini"
    },
    {
      "affs": [
        5
      ],
      "name": "Eleni Papakonstantinou",
      "orcid": "0000-0001-5274-8991"
    },
    {
      "affs": [
        5
      ],
      "name": "Daiana Stolz"
    },
    {
      "affs": [
        0,
        4,
        5,
        6
      ],
      "name": "Rodolfo P Vieira",
      "orcid": "0000-0001-6379-1143"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ardp012sx7xdg.bib",
  "cited_by": 0,
  "doi": "10.3390/jfmk11040434",
  "fulltext_url": "https://europepmc.org/articles/PMC13692514",
  "id": "ardp012sx7xdg",
  "issns": [
    "2411-5142"
  ],
  "landing_url": "https://europepmc.org/article/MED/42924713",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2737|Nutrition and Health in Aging"
    ]
  ],
  "openalex": "W7222980313",
  "pdf_url": "https://europepmc.org/articles/PMC13692514?pdf=render",
  "pmcid": "PMC13692514",
  "pmid": "42924713",
  "published": "2026-10-19",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ardp012sx7xdg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:33Z",
      "native_id": "MED:42924713",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42924713"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Nutrition and Health in Aging",
      "subfield": "physiology"
    }
  ],
  "title": "Resistance Training Improves Respiratory Muscle Strength and Immune Response in Older Adults: A Randomized Clinical Trial.",
  "title_text": "Resistance Training Improves Respiratory Muscle Strength and Immune Response in Older Adults: A Randomized Clinical Trial.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:33Z",
  "url": "https://research.draconitic.com/paper/ardp012sx7xdg",
  "venue": "Journal of functional morphology and kinesiology",
  "versions": []
}