{
  "abstract": "Disulfide modification typically relies on global reduction, preventing the selective manipulation of individual disulfide bonds within complex peptides. Here, we show that aromatic, ethyl, and tert-butyl disulfides embedded in fully unprotected peptides exhibit distinct intrinsic reactivities that can be selectively decoded by using matched activation modes. This architecture-guided hierarchy enables sequential chemoselective functionalization without the use of protecting groups. Aromatic disulfides further undergo an orthogonal phosphite-mediated transformation, expanding the repertoire of programmable disulfide editing.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Chemistry, Emory University, Atlanta, Georgia30322, United States."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Samrat Kundu"
    },
    {
      "affs": [
        0
      ],
      "name": "Adrija Majumdar"
    },
    {
      "affs": [
        0
      ],
      "name": "Monika Raj",
      "orcid": "0000-0001-9636-2222"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/arghqe4d93sz4.bib",
  "cited_by": 0,
  "doi": "10.1021/acs.orglett.6c03451",
  "fulltext_url": "https://europepmc.org/articles/PMC13660385",
  "id": "arghqe4d93sz4",
  "issns": [
    "1523-7060",
    "1523-7052"
  ],
  "landing_url": "https://europepmc.org/article/MED/42912240",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Chemical Synthesis and Analysis"
    ]
  ],
  "openalex": "W7214746184",
  "pdf_url": "https://europepmc.org/articles/PMC13660385?pdf=render",
  "pmcid": "PMC13660385",
  "pmid": "42912240",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/arghqe4d93sz4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:14Z",
      "native_id": "MED:42912240",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42912240"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Chemical Synthesis and Analysis",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Architecture-Guided Sequential Editing of Distinct Disulfides in Unprotected Peptides.",
  "title_text": "Architecture-Guided Sequential Editing of Distinct Disulfides in Unprotected Peptides.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:14Z",
  "url": "https://research.draconitic.com/paper/arghqe4d93sz4",
  "venue": "Organic letters",
  "versions": []
}