{
  "abstract": "Background/purpose\n\nIn Asia, oral squamous cell carcinoma (OSCC) are on the rise in part due to the consumption of betel nut in several regions. This clinical case study evaluated the application of the microtube array membrane-hollow fiber assay (MTAM-HFA) that was previously clinically demonstrated in the context of the selection of chemotheraputic agents as part of the treatment of concurrent chemoradiotherapy (CCRT) in OSCC.Materials and methods\n\nIn this double-blind cohort study, surgical samples from OSCC patients were retrieved and sent for screening of tumor response against a panel of chemotherapeutic agents (5-fluorouracil (5-FU), cisplatin, carboplatin and docetaxel). Screening outcomes were compared to the clinical outcome of patients receiving the same agents.Results\n\nMTAM-HFA could predict clinical response of all 3 patients. In patient 1 and 2, MTAM-HFA screening predicted the chemotherapeutic agents accurately which was reflected in the clinical outcome of these respective patients where a significant and stable regression of tumor was observed. In patient 3, the MTAM-HFA screening revealed that 5-FU and cisplatin would exhibit limited anticancer effect. Clinically, after being administered a cocktail of docetaxel, cisplatin and 5-FU, the tumor regressed initially. However, tumor progression was noted after 2nd neoadjuvant chemotherapy. Anticancer drug resistance was later identified resulting in the need for multimodal approach.Conclusion\n\nOverall, the outcomes were aligned with MTAM-HFA predictions, validating the ability to predict the anti-cancer effects of drugs. This highlights MTAM-HFA as a promising precision oncology system; with a larger prospective interventional clinical study planned for future validation.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Oral and Maxillofacial Surgery, Department of Stomatology, Taipei Municipal Wanfang Hospital, Taipei, Taiwan.",
    "Department of Dentistry, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.",
    "Institute of Oral Medicine and Materials, College of Medicine, Tzu Chi University, Hualien, Taiwan.",
    "Graduate Institute of Biomedical Materials and Tissue Engineering, Taipei Medical University, Taipei, Taiwan.",
    "Translational Autoinflammatory Disease Section (TADS), Laboratory of Clinical Immunology and Microbiology (LCIM), National Institutes of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.",
    "Department of Otolaryngology, Taipei Municipal Wanfang Hospital, Taipei, Taiwan.",
    "Department of Hematology-Oncology, Taipei Municipal Wanfang Hospital, Taipei Medical University, Taipei, Taiwan.",
    "International PhD Program for Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.",
    "Ph.D Program in Biotechnology Research and Development, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.",
    "International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan.",
    "School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.",
    "Division of Oral and Maxillofacial Surgery, Department of Dentistry, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shan-Ju Chou"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Po-Chih Hsu"
    },
    {
      "affs": [
        3
      ],
      "name": "Chee Ho Chew"
    },
    {
      "affs": [
        3
      ],
      "name": "Wan-Ting Huang"
    },
    {
      "affs": [
        4
      ],
      "name": "Amanda Lin Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Chen-Yin Yong"
    },
    {
      "affs": [
        5
      ],
      "name": "Chia-Che Wu"
    },
    {
      "affs": [
        6
      ],
      "name": "Chia-Lun Chang"
    },
    {
      "affs": [
        3,
        7,
        8,
        9
      ],
      "name": "Chien-Chung Chen"
    },
    {
      "affs": [
        0,
        10,
        11
      ],
      "name": "Kuan-Chou Lin"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/arhznktxx26dg.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jds.2025.07.3514",
  "fulltext_url": "https://europepmc.org/articles/PMC13689606",
  "id": "arhznktxx26dg",
  "issns": [
    "1991-7902",
    "2213-8862"
  ],
  "landing_url": "https://europepmc.org/article/MED/42923691",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2733|Head and Neck Cancer Studies"
    ]
  ],
  "openalex": "W7223555734",
  "pdf_url": "https://europepmc.org/articles/PMC13689606?pdf=render",
  "pmcid": "PMC13689606",
  "pmid": "42923691",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/arhznktxx26dg.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:36Z",
      "native_id": "MED:42923691",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42923691"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2733|Head and Neck Cancer Studies",
      "subfield": "general"
    }
  ],
  "title": "Hollow fiber assay microtube array membrane (MTAM-HFA) for personalized anticancer drug screening in selection of concurrent chemoradiotherapy in oral squamous cell carcinoma.",
  "title_text": "Hollow fiber assay microtube array membrane (MTAM-HFA) for personalized anticancer drug screening in selection of concurrent chemoradiotherapy in oral squamous cell carcinoma.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:36Z",
  "url": "https://research.draconitic.com/paper/arhznktxx26dg",
  "venue": "Journal of dental sciences",
  "versions": []
}