{
  "abstract": "Cell cycle transitions are driven by cyclins in complex with cyclin-dependent kinases (CDK). Here, we demonstrate that cyclin B3, an evolutionarily divergent B-type cyclin previously thought to function exclusively in female meiosis, is expressed in mitotic cells and interacts with both CDK1 and CDK2. We show that cyclin B3-CDK1/2 is essential for timely mitotic progression by ensuring proper chromosome alignment and stable kinetochore-microtubule interactions, while its overexpression accelerates mitosis and improves chromosome alignment kinetics. Through phospho-mass spectrometry, we identify several kinetochore and mitotic spindle components as substrates of cyclin B3-CDK1/2 in mitosis. Notably, cyclin B3 depletion disrupts mitotic progression in most cancer cell lines tested - including colorectal, osteosarcoma, and breast cancer models - while non-transformed cells are largely unaffected. These findings identify cyclin B3-CDK1/2 as a novel driver of mitotic progression and reveal a preferential dependency in a subset of cancer cells that may represent a potential therapeutic vulnerability.",
  "abstract_shown": true,
  "affiliations": [
    "University of California, Irvine"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "name": "A. Kizhedathu"
    },
    {
      "name": "A. C. N. Nguyen"
    },
    {
      "name": "C. Yu"
    },
    {
      "name": "S. Moghareh"
    },
    {
      "name": "V. Tran"
    },
    {
      "name": "P. Mousaian"
    },
    {
      "name": "J. Vertiz"
    },
    {
      "name": "C. A. Benavente"
    },
    {
      "name": "L. Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "P. Lara-Gonzalez"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/arnvfdxh9fzby.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.28.754947",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.28.754947v1.full",
  "id": "arnvfdxh9fzby",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.28.754947v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "cancer biology"
    ],
    [
      "openalex",
      "1307|Microtubule and mitosis dynamics"
    ]
  ],
  "openalex": "W7214765917",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.28.754947v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-28",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/arnvfdxh9fzby.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:25:02Z",
      "native_id": "10.64898/2026.09.28.754947",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.28.754947v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "biorxiv:cancer biology",
      "subfield": "oncology"
    }
  ],
  "title": "A meiotic B-type cyclin selectively drives mitotic progression and fidelity in cancer cells",
  "title_text": "A meiotic B-type cyclin selectively drives mitotic progression and fidelity in cancer cells",
  "type": "preprint",
  "updated_at": "2026-10-30T12:25:02Z",
  "url": "https://research.draconitic.com/paper/arnvfdxh9fzby",
  "venue": "bioRxiv",
  "versions": []
}