{
  "abstract": "Rationale: Tuberculosis preventive therapy (TPT) is essential for global tuberculosis control, yet estimated coverage remains well below global targets. Current World Health Organization (WHO)-recommended regimens require 1-9 months of treatment and are associated with suboptimal completion rates. Long-acting injectable (LAI) formulations offer the potential to improve TPT uptake and completion, with ideal products providing \"one-and-done\" options via a single administration. Sorfequiline, a second-generation diarylquinoline with superior potency over bedaquiline and lower QT prolongation risk, is a promising candidate for LAI TPT.",
  "abstract_shown": true,
  "affiliations": [
    "Johns Hopkins University School of Medicine"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "S.-Y. Li"
    },
    {
      "name": "J. J. Hobson"
    },
    {
      "name": "N. C. Ammerman"
    },
    {
      "name": "H. Pertinez"
    },
    {
      "name": "J. Sharp"
    },
    {
      "name": "N. Fotouhi"
    },
    {
      "name": "S. Rannard"
    },
    {
      "name": "A. Owen"
    },
    {
      "affs": [
        0
      ],
      "name": "E. L. Nuermberger"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/as2eap3tznxwj.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.22.752266",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.22.752266v1.full",
  "id": "as2eap3tznxwj",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.22.752266v1",
  "language": null,
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "microbiology"
    ],
    [
      "openalex",
      "2725|Tuberculosis Research and Epidemiology"
    ]
  ],
  "openalex": "W7214221371",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.22.752266v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-22",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/as2eap3tznxwj.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:24:25Z",
      "native_id": "10.64898/2026.09.22.752266",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.22.752266v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:microbiology",
      "subfield": "microbiology"
    }
  ],
  "title": "One-Dose Efficacy of Long-Acting Sorfequiline in a Mouse Model of Tuberculosis Preventive Therapy",
  "title_text": "One-Dose Efficacy of Long-Acting Sorfequiline in a Mouse Model of Tuberculosis Preventive Therapy",
  "type": "preprint",
  "updated_at": "2026-10-30T12:24:25Z",
  "url": "https://research.draconitic.com/paper/as2eap3tznxwj",
  "venue": "bioRxiv",
  "versions": []
}