{
  "abstract": "Background/Objectives: Chemotherapy-induced cardiotoxicity is a serious complication in breast cancer treatment, particularly with anthracyclines and HER2-targeted therapy. To evaluate the association between early elevations of cardiac markers (troponin and NT-proBNP) and the development of chemotherapy-induced cardiotoxicity in adult patients with breast cancer. Methods: This systematic review and meta-analysis were conducted according to PRISMA guidelines and registered with PROSPERO (CRD420261301170). A systematic search of PubMed/MEDLINE, Cochrane CENTRAL, and Web of Science databases was conducted. Studies evaluating cardiac markers in breast cancer patients receiving chemotherapy were included in the review. Results: Fourteen studies were included in the qualitative synthesis. Five studies were included in the meta-analysis. Elevated troponin levels were associated with higher odds of subsequent cardiac dysfunction; however, the pooled association was not statistically significant [OR = 3.40, 95% CI 0.69–16.67, p = 0.13] and showed substantial heterogeneity [I2 = 86.97%]. A leave-one-out sensitivity analysis was used to identify a study that exerted a substantial influence; its exclusion eliminated between-group heterogeneity and attenuated the pooled effect estimate. Conclusions: Early troponin elevation may provide a biological signal of myocardial injury during cancer therapy. However, the association between elevated troponin level and cancer therapy-related cardiac dysfunction did not reach the threshold of statistical significance and showed substantial heterogeneity. Troponin and NT-proBNP may provide complementary information to cardiac imaging, but their predictive performance and clinical utility require further prospective validation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biomedical Sciences, School of Medicine, Nazarbayev University, 5/1 Kerey and Zhanibek Khandar str., Astana 010000, Kazakhstan",
    "Department of Biology and Biotechnology, Faculty of Science, The Hashemite University, Zarqa 13133, Jordan",
    "Institute of Medical Science Technology [UniKL MESTECH], Universiti Kuala Lumpur, A1-1, Jalan TKS 1, Taman Kajang Sentral, Kajang 43000, Selangor, Malaysia",
    "National Laboratory Astana, Center of Life Sciences, Nazarbayev University, Astana 010000, Kazakhstan"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Nazym Askambayeva",
      "orcid": "0009-0004-3462-3609"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhuldyz Myrzabay",
      "orcid": "0009-0001-8730-5768"
    },
    {
      "affs": [
        1
      ],
      "name": "Ahmad J. Harahsheh"
    },
    {
      "affs": [
        2
      ],
      "name": "Reezal Ishak",
      "orcid": "0000-0001-7518-7365"
    },
    {
      "affs": [
        0
      ],
      "name": "Aigerim Biniyazova",
      "orcid": "0009-0004-8111-8568"
    },
    {
      "affs": [
        0,
        2,
        3
      ],
      "name": "Mohamad Aljofan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/as3254jzwr4tc.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15207882",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13706556/?tool=EBI",
  "id": "as3254jzwr4tc",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/20/7882",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2705|Chemotherapy-induced cardiotoxicity and mitigation"
    ]
  ],
  "openalex": "W7221688181",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13706556/pdf/?tool=EBI",
  "pmcid": "PMC13706556",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/as3254jzwr4tc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:00Z",
      "native_id": "10.3390/jcm15207882",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/20/7882"
    },
    {
      "first_seen": "2026-10-30T12:21:25Z",
      "native_id": "PMC:PMC13706556",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13706556"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Chemotherapy-induced cardiotoxicity and mitigation",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Early Cardiac Biomarkers for the Detection of Cancer Therapy-Related Cardiac Dysfunction in Breast Cancer: A Systematic Review and Meta-Analysis",
  "title_text": "Early Cardiac Biomarkers for the Detection of Cancer Therapy-Related Cardiac Dysfunction in Breast Cancer: A Systematic Review and Meta-Analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:25Z",
  "url": "https://research.draconitic.com/paper/as3254jzwr4tc",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}