{
  "abstract": "Cilia are present in most cells and are vital components in signal transduction and developmental control. Although Ca²⁺ signaling has been recognized as a key regulator of these ciliary functions, the potential contribution of Store-operated calcium entry (SOCE) to this regulation has not been investigated. In this study, we provide evidence that SOCE is required for ciliogenesis and cilia-dependent signaling. SOCE dysfunction results in a significant reduction in both the percentage of ciliated cells and the average length of cilia. Conversely, SOCE activation enhances the Sonic Hedgehog (Shh) pathway, a crucial cilia-dependent signaling pathway. Impaired SOCE disrupts both ciliogenesis and Shh signaling in Xenopus and mice, leading to abnormal embryonic development, including defective Left-Right (LR) asymmetry and limb bud formation. Our findings establish Orai1 as a key ciliary Ca²⁺ channel driving ciliogenesis and Shh signaling, uncovering a fundamental mechanism of developmental regulation and linking Ca²⁺ dysregulation to ciliopathies.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biomedical Engineering, College of Information-Bio Convergence Engineering, Ulsan National Institute of Science and Technology, Ulsan, 44919, Republic of Korea.",
    "Department of Biological Sciences, College of Information-Bio Convergence Engineering, Ulsan National Institute of Science and Technology, Ulsan, 44919, Republic of Korea.",
    "Department of Biological Sciences, College of Information-Bio Convergence Engineering, Ulsan National Institute of Science and Technology, Ulsan, 44919, Republic of Korea. parktj@unist.ac.kr.",
    "Department of Biomedical Engineering, College of Information-Bio Convergence Engineering, Ulsan National Institute of Science and Technology, Ulsan, 44919, Republic of Korea. cypark@unist.ac.kr."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yeong Cheon Kweon"
    },
    {
      "affs": [
        1
      ],
      "name": "Dong Gil Jang"
    },
    {
      "affs": [
        1
      ],
      "name": "Yoon Young Lee"
    },
    {
      "affs": [
        0
      ],
      "name": "Ah Reum Lee"
    },
    {
      "affs": [
        2
      ],
      "name": "Tae Joo Park"
    },
    {
      "affs": [
        3
      ],
      "name": "Chan Young Park"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/as81k5d3skwm1.bib",
  "cited_by": 0,
  "doi": "10.1186/s12964-026-03065-x",
  "fulltext_url": "https://europepmc.org/articles/PMC13729650",
  "id": "as81k5d3skwm1",
  "issns": [
    "1478-811X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42972548",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "1311|Genetic and Kidney Cyst Diseases"
    ]
  ],
  "openalex": "W7196969704",
  "pdf_url": "https://europepmc.org/articles/PMC13729650?pdf=render",
  "pmcid": "PMC13729650",
  "pmid": "42972548",
  "published": "2026-08-06",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/as81k5d3skwm1.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:44Z",
      "native_id": "MED:42972548",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42972548"
    },
    {
      "first_seen": "2026-11-07T12:22:22Z",
      "native_id": "PMC13729650",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12964-026-03065-x"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|Genetic and Kidney Cyst Diseases",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Orai1 Ca²⁺ channel is involved in ciliogenesis and cooperates with Shh signaling during LR asymmetry and limb bud formation.",
  "title_text": "Orai1 Ca²⁺ channel is involved in ciliogenesis and cooperates with Shh signaling during LR asymmetry and limb bud formation.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:22Z",
  "url": "https://research.draconitic.com/paper/as81k5d3skwm1",
  "venue": "Cell communication and signaling : CCS",
  "versions": []
}