{
  "abstract": "Artificial Intelligence virtual cell (AIVC) holds transformative potential for biomedical research. Central to this vision is the systematic modeling of genetic and chemical perturbation phenotypes to accurately predict cellular dynamic states from diverse interventions. However, disparities in screening agents, library scales, experimental technologies, and data production efficiency hinder the integration, modeling, and analysis of the cross-data. Here we present UniPert-G2CP , a two-phase deep learning approach comprising i) UniPert, a multimodal molecular representation model that bridges genetic and chemical domains, and ii) G2CP ( Genetic-to-Chemical Perturbation transfer learning), which systematically transforms CRISPR screen-based genetic insights into chemical perturbation modeling for cost-effective in silico drug screening. UniPert not only encodes multimodal perturbagens into a unified functionally interpretable sematic embedding space, but also improves phenotypic effect prediction for previously unseen gene perturbations and drug treatments. Building upon UniPert, G2CP successfully modeled large-scale cellular post-perturbation states spanning 4,994 gene and 7,821 compound perturbagens, while reducing modeling data costs by over 60%. We demonstrate that UniPert-G2CP enables efficient, generalizable simulations of multicellular, multi-domain perturbation cause-effect spaces, revealing differential cellular biological causality and informing mechanism-driven therapy. UniPert-G2CP opens new avenues for biological causal foundation model building, AIVC creation, and AI-powered precision medicine.",
  "abstract_shown": true,
  "affiliations": [
    "Hunan Provincial Key Laboratory on Bioinformatics, School of Computer Science and Engineering, Central South University, Changsha 410083, China; AI for Life Sciences Lab, Tencent, Shenzhen, China",
    "Hunan Provincial Key Laboratory on Bioinformatics, School of Computer Science and Engineering, Central South University, Changsha 410083, China",
    "AI for Life Sciences Lab, Tencent, Shenzhen, China; Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China",
    "AI for Life Sciences Lab, Tencent, Shenzhen, China; Department of Computer Science, City University of Hong Kong, Hong Kong, China",
    "AI for Life Sciences Lab, Tencent, Shenzhen, China",
    "AI for Life Sciences Lab, Tencent, Shenzhen, China; Department of Computer Science, Hong Kong Baptist University, Hong Kong, China",
    "AI for Life Sciences Lab, Tencent, Shenzhen, China. Electronic address: fionafyang@tencent.com",
    "Hunan Provincial Key Laboratory on Bioinformatics, School of Computer Science and Engineering, Central South University, Changsha 410083, China. Electronic address: limin@mail.csu.edu.cn",
    "AI for Life Sciences Lab, Tencent, Shenzhen, China. Electronic address: jianhuayao@tencent.com"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yiming Li",
      "orcid": "0000-0003-2111-3939"
    },
    {
      "affs": [
        1
      ],
      "name": "Min De ZENG",
      "orcid": "0000-0001-6472-1980"
    },
    {
      "affs": [
        2
      ],
      "name": "Jun Zhu"
    },
    {
      "affs": [
        3
      ],
      "name": "Linjing Liu",
      "orcid": "0000-0002-2366-4593"
    },
    {
      "affs": [
        4
      ],
      "name": "Fang Wang",
      "orcid": "0000-0002-5971-2622"
    },
    {
      "affs": [
        5
      ],
      "name": "L L Huang",
      "orcid": "0009-0003-4609-3177"
    },
    {
      "affs": [
        6
      ],
      "name": "Fan Yang"
    },
    {
      "affs": [
        7
      ],
      "name": "Min Li",
      "orcid": "0000-0002-0188-1394"
    },
    {
      "affs": [
        8
      ],
      "name": "Jianhua Yao",
      "orcid": "0000-0001-9157-9596"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/aszmzr6bz90wt.bib",
  "cited_by": 9,
  "doi": "10.1016/j.cell.2026.06.005",
  "fulltext_url": null,
  "id": "aszmzr6bz90wt",
  "issns": [
    "0092-8674",
    "1097-4172"
  ],
  "landing_url": "https://doi.org/10.1016/j.cell.2026.06.005",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "3002|Computational Drug Discovery Methods"
    ]
  ],
  "openalex": "W7170437617",
  "pdf_url": null,
  "pmcid": null,
  "pmid": "42497867",
  "published": "2026-07-25",
  "publisher": "Cell Press",
  "ris": "https://research.draconitic.com/paper/aszmzr6bz90wt.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T13:21:00Z",
      "native_id": "W7170437617",
      "source": "openalex",
      "url": "https://doi.org/10.1016/j.cell.2026.06.005"
    }
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  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:3002|Computational Drug Discovery Methods",
      "subfield": "medicinal"
    }
  ],
  "title": "UniPert-G2CP bridges genetic and chemical screens from molecular representation to phenotype modeling",
  "title_text": "UniPert-G2CP bridges genetic and chemical screens from molecular representation to phenotype modeling",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:17Z",
  "url": "https://research.draconitic.com/paper/aszmzr6bz90wt",
  "venue": "Cell",
  "versions": []
}