{
  "abstract": "Background\n\nCerebral amyloid angiopathy (CAA) is strongly associated with Alzheimer's disease neuropathologic changes (ADNC), but its links with other brain pathologies remain unclear.Methods\n\nWe conducted a clinicopathological study of 3,267 participants from the National Alzheimer's Coordinating Center (NACC) cohort. Neuropathological evaluations included potential risk factors for CAA, such as ADNC, Lewy body pathology (LBP), frontotemporal lobar degeneration (FTLD), and other neuropathologies.Results\n\nWe found that ADNC and LBP were associated with increased odds of CAA, with the risk increasing according to ADNC severity and in cases of limbic/amygdala-predominant LBP. In contrast, FTLD, particularly the FTLD-TDP subtype, was inversely associated with CAA. Among other neuropathologies, CAA was positively associated with microinfarcts, arteriolosclerosis, white matter rarefaction, and hippocampus/cortical atrophy, but inversely associated with lobar atrophy and higher brain weight. In addition, APOE ε4 carriers with mixed ADNC, LBP, and FTLD exhibited the highest risk. Stronger associations between ADNC and CAA were observed in participants aged < 80 years and in males, whereas females demonstrated greater vulnerability to vascular- and atrophy-related correlates. Several neuropathology-CAA associations were also more pronounced among APOE ε4 carriers.Conclusion\n\nThese findings highlight the interplay of neurodegenerative, vascular, sex, and APOE ε4 in CAA susceptibility, with implications for risk stratification.",
  "abstract_shown": true,
  "affiliations": [
    "School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia.",
    "Australia BioCommons, The University of Melbourne, 21 Bedford Street, North Melbourne, VIC, 3051, Australia.",
    "School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia. liang.jin@monash.edu.",
    "School of Translational Medicine, Monash University, 99 Commercial Road, Melbourne, VIC, 3004, Australia. yijun.pan@monash.edu.",
    "School of Health and Biomedical Sciences, RMIT University, 30 Janefield Drive, Bundoora, VIC, 3083, Australia. yijun.pan@monash.edu."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Liwei Ma"
    },
    {
      "affs": [
        0
      ],
      "name": "Yihan Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Benjamin Goudey"
    },
    {
      "affs": [
        2
      ],
      "name": "Liang Jin"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Yijun Pan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/at3c407c0yam1.bib",
  "cited_by": 0,
  "doi": "10.1186/s13195-026-02064-x",
  "fulltext_url": "https://europepmc.org/articles/PMC13721479",
  "id": "at3c407c0yam1",
  "issns": [
    "1758-9193"
  ],
  "landing_url": "https://europepmc.org/article/MED/42958434",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2728|Intracerebral and Subarachnoid Hemorrhage Research"
    ]
  ],
  "openalex": "W7172098044",
  "pdf_url": "https://europepmc.org/articles/PMC13721479?pdf=render",
  "pmcid": "PMC13721479",
  "pmid": "42958434",
  "published": "2026-08-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/at3c407c0yam1.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:47Z",
      "native_id": "MED:42958434",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42958434"
    },
    {
      "first_seen": "2026-11-03T12:22:10Z",
      "native_id": "PMC13721479",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s13195-026-02064-x"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Intracerebral and Subarachnoid Hemorrhage Research",
      "subfield": "neurology"
    }
  ],
  "title": "Neuropathological and vascular determinants of cerebral amyloid angiopathy risk: evidence from the NACC cohort.",
  "title_text": "Neuropathological and vascular determinants of cerebral amyloid angiopathy risk: evidence from the NACC cohort.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:22:10Z",
  "url": "https://research.draconitic.com/paper/at3c407c0yam1",
  "venue": "Alzheimer's research & therapy",
  "versions": []
}