{
  "abstract": "Bladder cancer (BLCA) is a urinary system malignant tumor with high morbidity and mortality worldwide. There is an urgent need for new biomarkers and therapeutic targets. By integrating single-cell RNA sequencing, MitoCarta database and the Cancer Genome Atlas data, this study found that mitochondrial ribosomal protein L37 (MRPL37) was significantly up-regulated in BLCA, and its expression level was related to disease progression and poor prognosis. Functional experiments in vitro and in vivo confirmed that knockdown of MRPL37 could inhibit the proliferation, invasion, migration, metabolism and cisplatin resistance of BLCA cells by cell experiments, mouse subcutaneous tumor model, mouse orthotopic bladder cancer model and patient-derived organoid (PDO) model. A novel MRPL37-LRPPRC-ROS-AKT signaling axis was identified: loss of MRPL37 leads to the disorder of branched-chain amino acid metabolism, down-regulates the key mitochondrial protein LRPPRC, and then causes mitochondrial membrane potential damage and reactive oxygen species accumulation, which ultimately exert anti-cancer effect by inhibiting the AKT pathway. This study not only advances the understanding of the mechanism by which mitochondrial translation defects drive tumorigenesis, but also highlights the potential of MRPL37 as a target in BLCA prognosis and targeted therapy.",
  "abstract_shown": true,
  "affiliations": [
    "Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, University Engineering Research Center of Digital Medicine and Healthcare, Guangxi Medical University, Nanning, Guangxi, 530021, China.",
    "School of Life Sciences, Guangxi Medical University, Nanning, Guangxi, China.",
    "Department of Urology, Guangxi Hospital Division of the First Affiliated Hospital, Sun Yat-sen University, Nanning, Guangxi, 530022, China.",
    "Department of Urology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, China.",
    "Department of Urology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, P.R. China.",
    "Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",
    "Institute of Biomedical Research, Department of Infectious Diseases, Regulatory Mechanism and Targeted Therapy for Liver Cancer Shiyan Key Laboratory, Hubei Provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver Cancer, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, China. 17693448525@163.com.",
    "Hubei Key Laboratory of Embryonic Stem Cell Research, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, China. 17693448525@163.com.",
    "Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, University Engineering Research Center of Digital Medicine and Healthcare, Guangxi Medical University, Nanning, Guangxi, 530021, China. wangfubo@gxmu.edu.cn.",
    "School of Life Sciences, Guangxi Medical University, Nanning, Guangxi, China. wangfubo@gxmu.edu.cn."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 20,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Xieyuan Leng"
    },
    {
      "affs": [
        2
      ],
      "name": "Wenhao Lu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Rongbin Zhou"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Chengbang Wang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Zuheng Wang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Haodong Peng"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yitong Guo"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Baoyu Huang"
    },
    {
      "affs": [
        3
      ],
      "name": "Dongwei Pan"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Dianyu Wang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Zequn Su"
    },
    {
      "affs": [
        4
      ],
      "name": "Xuanfan Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xuefang Liang"
    },
    {
      "affs": [
        0
      ],
      "name": "Tian Guo"
    },
    {
      "affs": [
        0
      ],
      "name": "Wen Liang"
    },
    {
      "affs": [
        0
      ],
      "name": "Wentin Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Zihang Huang"
    },
    {
      "affs": [
        5
      ],
      "name": "Zhe Chen"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Yigan Zhang"
    },
    {
      "affs": [
        8,
        9
      ],
      "name": "Fubo Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/at40y8nqex88x.bib",
  "cited_by": 0,
  "doi": "10.1186/s13062-026-00883-4",
  "fulltext_url": "https://europepmc.org/articles/PMC13700306",
  "id": "at40y8nqex88x",
  "issns": [
    "1745-6150"
  ],
  "landing_url": "https://europepmc.org/article/MED/42928237",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2746|Bladder and Urothelial Cancer Treatments"
    ]
  ],
  "openalex": "W7171723772",
  "pdf_url": "https://europepmc.org/articles/PMC13700306?pdf=render",
  "pmcid": "PMC13700306",
  "pmid": "42928237",
  "published": "2026-07-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/at40y8nqex88x.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:20Z",
      "native_id": "MED:42928237",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42928237"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Bladder and Urothelial Cancer Treatments",
      "subfield": "surgery"
    }
  ],
  "title": "Targeting MRPL37 disrupts the pro-tumorigenic mitochondrial cascade in bladder cancer: from LRPPRC deficiency to ROS/AKT axis inhibition.",
  "title_text": "Targeting MRPL37 disrupts the pro-tumorigenic mitochondrial cascade in bladder cancer: from LRPPRC deficiency to ROS/AKT axis inhibition.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:20Z",
  "url": "https://research.draconitic.com/paper/at40y8nqex88x",
  "venue": "Biology direct",
  "versions": []
}