{
  "abstract": "Chronic hemolytic anemia found in patients with sickle cell disease promotes an excess of free extracellular and intravascular hemoglobin, triggering a series of deleterious effects such as endothelial dysfunction, oxidative stress, and alterations in vascular tone, which lead to clinical complications. In this work, we evaluated the induced expression of haptoglobin in hepatocytes in vivo, the organism’s first line of defense to control the presence of free Hb in circulation, which becomes saturated in conditions of chronic hemolysis, such as sickle cell disease. Through gene therapy applied in a murine model of sickle cell anemia, we aimed to investigate whether this approach could interfere with disease progression and promote an improvement in the animals’ pathophysiological condition. The application of this treatment in the sickle cell anemia animal model resulted in significant therapeutic effects, including improvement of hematological parameters, reduction of the compensatory erythropoietic response, and attenuation of clinical signs such as splenomegaly. These results indicate that haptoglobin may act indirectly in the prevention of hemolysis, suggesting a new therapeutic approach.",
  "abstract_shown": true,
  "affiliations": [
    "Laboratory for the Development of Biological Models, Multidisciplinary Center for Biological Research, University of Campinas (UNICAMP), Campinas, SP, Brazil",
    "Department of Pathology, Hemoglobinopathies Laboratory, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil",
    "Department of Pathology, Hematology Laboratory, Clinical Pathology Laboratory (LPC), University Hospital, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil",
    "Center for Hematology and Hemotherapy, National Institute of Science and Technology in Blood (INCTS), University of Campinas (UNICAMP), Campinas, SP, Brazil"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Bianca Cristina dos Santos"
    },
    {
      "affs": [
        1
      ],
      "name": "Magnun Nueldo Nunes dos Santos"
    },
    {
      "affs": [
        2
      ],
      "name": "Gisele Audrei Pedroso"
    },
    {
      "affs": [
        3
      ],
      "name": "Beatriz Benedetti de Oliveira"
    },
    {
      "name": "Dulcinéia Martins de Albuquerque"
    },
    {
      "name": "Nathalia Rocha de Oliveira"
    },
    {
      "name": "Daniela Cagnoto Noronha"
    },
    {
      "name": "Fernando Ferreira Costa"
    },
    {
      "name": "Marcus Alexandre Finzi Corat"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/at4wyja5j74em.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0357180",
  "fulltext_url": null,
  "id": "at4wyja5j74em",
  "issns": [
    "1932-6203"
  ],
  "landing_url": "https://doi.org/10.1371/journal.pone.0357180",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2716|Hemoglobinopathies and Related Disorders"
    ],
    [
      "plos",
      "/Biology and life sciences/Biochemistry/Proteins/Hemoglobin"
    ],
    [
      "plos",
      "/Biology and life sciences/Biochemistry/Proteins/Plasma proteins/Haptoglobins"
    ],
    [
      "plos",
      "/Biology and life sciences/Cell biology/Cellular types/Animal cells/Blood cells/Red blood cells"
    ],
    [
      "plos",
      "/Biology and life sciences/Physiology/Immune physiology/Spleen"
    ],
    [
      "plos",
      "/Medicine and health sciences/Clinical genetics/Genetic diseases/Autosomal recessive diseases/Sickle cell disease"
    ],
    [
      "plos",
      "/Medicine and health sciences/Hematology"
    ],
    [
      "plos",
      "/Medicine and health sciences/Hematology/Hemoglobinopathies/Sickle cell disease"
    ],
    [
      "plos",
      "/Medicine and health sciences/Medical conditions/Genetic diseases/Autosomal recessive diseases/Sickle cell disease"
    ],
    [
      "plos",
      "/Medicine and health sciences/Surgical and invasive medical procedures/Blood and lymphatic system procedures/Bone marrow transplantation"
    ],
    [
      "plos",
      "/Medicine and health sciences/Surgical and invasive medical procedures/Transplantation/Bone marrow transplantation"
    ],
    [
      "plos",
      "/Research and analysis methods/Animal studies/Experimental organism systems/Animal models/Mouse models"
    ],
    [
      "plos",
      "/Research and analysis methods/Animal studies/Experimental organism systems/Model organisms/Mouse models"
    ],
    [
      "plos",
      "/Research and analysis methods/Model organisms/Mouse models"
    ]
  ],
  "openalex": "W7213543014",
  "pdf_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0357180&type=printable",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-18",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/at4wyja5j74em.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:49Z",
      "native_id": "10.1371/journal.pone.0357180",
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      "url": "https://doi.org/10.1371/journal.pone.0357180"
    }
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  "subjects": [
    {
      "field": "biology",
      "origin": "plos:cell biology",
      "subfield": "cell-biology"
    },
    {
      "field": "medicine",
      "origin": "plos:physiology",
      "subfield": "physiology"
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    {
      "field": "medicine",
      "origin": "plos:surgical and invasive medical procedures",
      "subfield": "surgery"
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  ],
  "title": "Therapeutic potential of haptoglobin in a murine model of sickle cell anemia",
  "title_text": "Therapeutic potential of haptoglobin in a murine model of sickle cell anemia",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:49Z",
  "url": "https://research.draconitic.com/paper/at4wyja5j74em",
  "venue": "PLOS One",
  "versions": []
}