{
  "abstract": "BACKGROUND: The optimal timing for lactate sampling during acetylcholine (ACh) provocation to detect metabolic ischemia remains unclear. METHODS AND RESULTS: In 20 patients with suspected INOCA, blood samples from the coronary artery and coronary sinus were obtained at baseline, every minute for 5 min after ACh, and after nitroglycerin. Metabolic ischemia (negative lactate extraction ratio) occurred in 12 patients: 10 patients exhibited ischemia at 1 min, and 2 patients only at 2 min. No ischemia was observed beyond 3 min. CONCLUSIONS: Sampling at both 1 and 2 min may reduce false-negative detection of metabolic ischemia during ACh provocation.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Tsuyoshi Ito"
    },
    {
      "name": "Masashi Yokoi"
    },
    {
      "name": "Shuichi Kitada"
    },
    {
      "name": "Yu Kawada"
    },
    {
      "name": "Tatsuya Mizoguchi"
    },
    {
      "name": "Sayuri Yamabe"
    },
    {
      "name": "Atsushi Niwa"
    },
    {
      "name": "Toshihiko Goto"
    },
    {
      "name": "Yoshihiro Seo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/at71jd4g1ay60.bib",
  "cited_by": 0,
  "doi": "10.1253/circj.cj-26-0032",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/circj/90/8/90_CJ-26-0032/_article",
  "id": "at71jd4g1ay60",
  "issns": [
    "1347-4820",
    "1346-9843"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/circj/90/8/90_CJ-26-0032/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/cardiovascular"
    ],
    [
      "openalex",
      "2741|Cardiac Imaging and Diagnostics"
    ]
  ],
  "openalex": "W7151915962",
  "pdf_url": "https://www.jstage.jst.go.jp/article/circj/90/8/90_CJ-26-0032/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-24",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/at71jd4g1ay60.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:24Z",
      "native_id": "10.1253/circj.cj-26-0032",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/circj/90/8/90_CJ-26-0032/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2741|Cardiac Imaging and Diagnostics",
      "subfield": "imaging"
    }
  ],
  "title": "Time-Dependent Analysis of Blood Sampling to Detect Metabolic Ischemia ― Serial Coronary Artery–Coronary Sinus Lactate Analysis During Acetylcholine Provocation ―",
  "title_text": "Time-Dependent Analysis of Blood Sampling to Detect Metabolic Ischemia ― Serial Coronary Artery–Coronary Sinus Lactate Analysis During Acetylcholine Provocation ―",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:24Z",
  "url": "https://research.draconitic.com/paper/at71jd4g1ay60",
  "venue": "Circulation Journal",
  "versions": []
}