{
  "abstract": "Background\n\nFinerenone improves cardiorenal outcomes in chronic kidney disease (CKD) with type 2 diabetes, but its effect on preventing new-onset heart failure (HF) in CKD is uncertain. We evaluated whether finerenone is associated with lower 1-year risk of incident HF and adverse cardiorenal events in CKD patients without prior HF.Methods\n\nIn the multi-institutional TriNetX research network, we identified adults with CKD between January 1, 2022, and September 30, 2025. New users of finerenone were compared with finerenone non-users. Propensity score matching (1:1) was performed based on demographics, comorbidities, medications, and key laboratory values. Follow-up began the day after the index date and continued for up to 1 year. The primary outcome was new-onset HF. HF was identified using diagnostic codes and treatment-based criteria; therefore, outcome misclassification cannot be completely excluded. Secondary outcomes were major adverse cardiovascular events (MACE: ischemic stroke, acute myocardial infarction, or death), major adverse kidney events (MAKE), and all-cause mortality. Cox models estimated hazard ratios (HRs) with 95% confidence intervals (CIs).Results\n\nAfter matching, 11,140 patients were included (mean age 67.5 years, 42.5% female). Finerenone use was associated with a lower 1-year risk of incident HF (4.9% vs. 8.0%; HR 0.68, 95% CI 0.59-0.79; P<.001). Finerenone use was also associated with lower risks of MACE (HR 0.67, 95% CI 0.56-0.81; P<.001), MAKE (HR 0.51, 95% CI 0.39-0.67), and all-cause mortality (HR 0.62, 95% CI 0.47-0.81; P<.001).Conclusions\n\nIn this large real-world CKD cohort without prior HF, finerenone use was associated with lower 1-year risks of incident HF, MACE, MAKE, and all-cause mortality compared with non-use. These findings suggest a potential association between finerenone use and a lower observed risk of HF among patients with CKD, although causal relationships cannot be established.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Nutrition, Chi Mei Medical Center, Tainan, Taiwan.",
    "Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan.",
    "Division of Cardiology, Department of Internal Medicine, Chi Mei Hospital, Chiali, Tainan, Taiwan.",
    "Department of Medical Education, Chi Mei Medical Center, Tainan, Taiwan.",
    "Division of Hepatogastroenterology, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan (R.O.C.). tnfsh801107@gmail.com.",
    "Division of Cardiology, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan (R.O.C.). xxpil305a@gmail.com."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Jheng-Yan Wu"
    },
    {
      "affs": [
        2
      ],
      "name": "Keng-Wei Lee"
    },
    {
      "affs": [
        3
      ],
      "name": "Sheng-Chi Huang"
    },
    {
      "affs": [
        4
      ],
      "name": "Hsuan-Yuan Chang"
    },
    {
      "affs": [
        5
      ],
      "name": "Yu-Min Lin",
      "orcid": "0009-0005-1723-828X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/at7bzbpyzgkb2.bib",
  "cited_by": 0,
  "doi": "10.1186/s12872-026-06384-6",
  "fulltext_url": "https://europepmc.org/articles/PMC13718172",
  "id": "at7bzbpyzgkb2",
  "issns": [
    "1471-2261"
  ],
  "landing_url": "https://europepmc.org/article/MED/42958056",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2727|Chronic Kidney Disease and Diabetes"
    ]
  ],
  "openalex": "W7172134826",
  "pdf_url": "https://europepmc.org/articles/PMC13718172?pdf=render",
  "pmcid": "PMC13718172",
  "pmid": "42958056",
  "published": "2026-08-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/at7bzbpyzgkb2.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T00:20:47Z",
      "native_id": "MED:42958056",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42958056"
    },
    {
      "first_seen": "2026-11-02T12:22:17Z",
      "native_id": "PMC13718172",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12872-026-06384-6"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:2705|Acute Myocardial Infarction Research",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Association between finerenone use and risk of new-onset heart failure in chronic kidney disease: a propensity-matched cohort study using the TriNetX network.",
  "title_text": "Association between finerenone use and risk of new-onset heart failure in chronic kidney disease: a propensity-matched cohort study using the TriNetX network.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:22:17Z",
  "url": "https://research.draconitic.com/paper/at7bzbpyzgkb2",
  "venue": "BMC cardiovascular disorders",
  "versions": []
}