{
  "abstract": "Immunotherapy has revolutionized the treatment landscape for many cancers, but fails to improve the outcomes of glioblastoma multiforme (GBM), in which low tumor antigen presentation restricts the recognition and eradication of cancerous cells by immunocytes. We here report an approach to in situ reprogramming hypoimmunogenic glioblastoma stem cells (GSCs) into type 1 conventional dendritic cell (cDC1)-like cells for presenting endogenous tumor antigens and priming sustained tumoricidal T-cell responses. Specifically, our cavity-injectable nucleobase-derived lipid nanoparticle (LNP)-hydrogel superstructure efficiently delivers transcription factors (PU.1, IRF8, BATF3) and the costimulatory molecule (TNFSF9) into GSCs to induce cDC1-like reprogramming. These cDC1-like cells potentiate GBM immunogenicity, elicit robust adaptive immunity and long-term antitumor memory, thereby inhibiting tumor growth and preventing postoperative GBM relapse in mice. Collectively, this work establishes in situ tumor cell reprogramming into licensed cDC1-like cells as a therapeutic paradigm for converting immunologically “cold” tumors into a self-vaccinating immune niche with broad translational potential for hypoimmunogenic malignancy treatment.",
  "abstract_shown": true,
  "affiliations": [
    "Shandong University of Traditional Chinese Medicine, Jinan, China",
    "Department of Neurosurgery, Qilu Hospital and Institute of Brain and Brain-Inspired Science, Cheeloo College of Medicine, Shandong University, Jinan, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 23,
  "authors": [
    {
      "name": "Chunwei Tang"
    },
    {
      "name": "Weiyi Sun"
    },
    {
      "name": "Zhenmei Yang"
    },
    {
      "name": "Xiaotian Zhao"
    },
    {
      "name": "Jian Gao"
    },
    {
      "name": "Kun Han"
    },
    {
      "name": "Zichao Yao"
    },
    {
      "name": "Xianghui Dong"
    },
    {
      "name": "Miaoyan Liu"
    },
    {
      "name": "Jing Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhaoyu Chen"
    },
    {
      "name": "Xiao Yue"
    },
    {
      "name": "Zhipeng Fu"
    },
    {
      "name": "Yan Wang"
    },
    {
      "name": "Maosen Han"
    },
    {
      "name": "Ying Liu"
    },
    {
      "name": "Jinxin Gao"
    },
    {
      "affs": [
        1
      ],
      "name": "Yulin Zhang",
      "orcid": "0000-0002-0031-1808"
    },
    {
      "name": "Xinyi Jiang",
      "orcid": "0000-0003-0074-6876"
    },
    {
      "name": "Chen Chen"
    },
    {
      "name": "Xin Wen"
    },
    {
      "name": "Kun Zhao",
      "orcid": "0000-0002-0457-5827"
    },
    {
      "name": "Jingyi Han",
      "orcid": "0000-0002-3765-2788"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/atvv6pa2nmw6s.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-78070-2",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13714278/",
  "id": "atvv6pa2nmw6s",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://doi.org/10.1038/s41467-026-78070-2",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2403|Immunotherapy and Immune Responses"
    ]
  ],
  "openalex": "W7214656519",
  "pdf_url": "https://www.nature.com/articles/s41467-026-78070-2_reference.pdf",
  "pmcid": "PMC13714278",
  "pmid": "42946748",
  "published": "2026-09-28",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/atvv6pa2nmw6s.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:21:48Z",
      "native_id": "PMC13714278",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41467-026-78070-2"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Immunotherapy and Immune Responses",
      "subfield": "immunology"
    }
  ],
  "title": "In situ reprogramming of glioma stem cells into dendritic cell-like cells for glioblastoma immunotherapy",
  "title_text": "In situ reprogramming of glioma stem cells into dendritic cell-like cells for glioblastoma immunotherapy",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:21:48Z",
  "url": "https://research.draconitic.com/paper/atvv6pa2nmw6s",
  "venue": "Nature Communications",
  "versions": []
}