{
  "abstract": "A new series of 2- and 4-substituted carbazole-derived nitrones was synthesized and evaluated for their antioxidant properties using multiple in vitro protocols, including inhibition of AAPH-induced lipid peroxidation, hydroxyl radical scavenging, ABTS•+–decolorization and DPPH interaction assays. Their anti-inflammatory capacity was investigated through the inhibition of soybean lipoxygenase (SLOX). Among all fourteen tested nitrones, compound 11bg emerged as the most promising derivative, exhibiting strong inhibition of lipid peroxidation and efficient hydroxyl radical scavenging activity. Nitrone 11be showed the highest lipoxygenase inhibition with an IC50 value of 0.0225 μM. Furthermore, seven of the fourteen synthesized hybrids showed strong SLOX inhibitory activity, with IC50 values below 30 μM.",
  "abstract_shown": true,
  "affiliations": [
    "Bioorganic Chemistry Laboratory, Faculty of Pharmacy, Medical University of Lodz, Muszyńskiego, 90-151 Lodz, Poland",
    "Laboratory of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece",
    "Laboratory of Medicinal Chemistry, Institute of General Organic Chemistry (CSIC), C/ Juan de la Cierva 3, 28006 Madrid, Spain"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Maciej J. Rojewski",
      "orcid": "0009-0009-2482-098X"
    },
    {
      "affs": [
        1
      ],
      "name": "Dimitra Hadjipavlou-Litina",
      "orcid": "0000-0002-1844-350X"
    },
    {
      "affs": [
        0
      ],
      "name": "Iwona E. Głowacka",
      "orcid": "0000-0001-7567-5860"
    },
    {
      "affs": [
        2
      ],
      "name": "Jose Marco-Contelles"
    },
    {
      "affs": [
        0
      ],
      "name": "Dorota G. Piotrowska",
      "orcid": "0000-0003-3792-8796"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/av6677n8762d9.bib",
  "cited_by": 0,
  "doi": "10.3390/molecules31203619",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13707573/?tool=EBI",
  "id": "av6677n8762d9",
  "issns": [
    "1420-3049"
  ],
  "landing_url": "https://www.mdpi.com/1420-3049/31/20/3619",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Free Radicals and Antioxidants"
    ]
  ],
  "openalex": "W7221556854",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13707573/pdf/?tool=EBI",
  "pmcid": "PMC13707573",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/av6677n8762d9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:42Z",
      "native_id": "10.3390/molecules31203619",
      "source": "crossref",
      "url": "https://www.mdpi.com/1420-3049/31/20/3619"
    },
    {
      "first_seen": "2026-10-30T12:21:31Z",
      "native_id": "PMC:PMC13707573",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13707573"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Free Radicals and Antioxidants",
      "subfield": "organic"
    }
  ],
  "title": "Antioxidant Activity of a New Series of Carbazole-Derived Nitrones",
  "title_text": "Antioxidant Activity of a New Series of Carbazole-Derived Nitrones",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:31Z",
  "url": "https://research.draconitic.com/paper/av6677n8762d9",
  "venue": "Molecules",
  "versions": []
}