{
  "abstract": "The Plastics-Active Enzyme Database (PAZy) is a manually curated resource for enzymes experimentally shown to act on synthetic or bio-based plastics. It was developed to distinguish experimentally verified plastics-active enzymes from computationally predicted or insufficiently supported candidates. Here, we present an expanded version of PAZy, implemented as a relational database containing >450 plastics-active enzymes with more detailed metadata, broader substrate coverage, and large language model-assisted curation of activity data. The redesigned web interface now enables browsing by protein or plastic substrate, detailed inspections of individual protein entries as well as programmatic access through a public representational state transfer (REST) application programming interface (API). This functionality enables scientists to freely implement PAZy into their own research workflows. By using evidence-based manual curation, PAZy provides a high-confidence resource for both comparative analyses and enzyme discovery in the rapidly growing field of enzymatic plastic degradation. PAZy is freely available at https://www.pazy.eu.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Microbiology and Biotechnology, University of Hamburg , D-22609 Hamburg ,",
    "Institute of Biochemistry, University of Stuttgart , D-70569 Stuttgart ,"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Golo Feuerriegel",
      "orcid": "0000-0003-0741-1729"
    },
    {
      "affs": [
        0
      ],
      "name": "Bjarne Ackers",
      "orcid": "0009-0004-2166-0013"
    },
    {
      "affs": [
        0
      ],
      "name": "Pablo Pérez-García",
      "orcid": "0000-0003-2248-3544"
    },
    {
      "affs": [
        1
      ],
      "name": "Jürgen Pleiss",
      "orcid": "0000-0003-1045-8202"
    },
    {
      "affs": [
        0
      ],
      "name": "Wolfgang R Streit",
      "orcid": "0000-0001-7617-7396"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/avd9dh0m1jm0k.bib",
  "cited_by": 0,
  "doi": "10.1093/nar/gkag1026",
  "fulltext_url": null,
  "id": "avd9dh0m1jm0k",
  "issns": [
    "0305-1048",
    "1362-4962"
  ],
  "landing_url": "https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkag1026/8937182",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1305|Enzyme Production and Characterization"
    ]
  ],
  "openalex": "W7222962949",
  "pdf_url": "https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkag1026/72085390/gkag1026.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-19",
  "publisher": "Oxford University Press (OUP)",
  "ris": "https://research.draconitic.com/paper/avd9dh0m1jm0k.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:50Z",
      "native_id": "10.1093/nar/gkag1026",
      "source": "crossref",
      "url": "https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkag1026/8937182"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1305|Enzyme Production and Characterization",
      "subfield": "systems-synthetic"
    }
  ],
  "title": "PAZy: an expanded and actively maintained database of experimentally validated plastic-active enzymes",
  "title_text": "PAZy: an expanded and actively maintained database of experimentally validated plastic-active enzymes",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:50Z",
  "url": "https://research.draconitic.com/paper/avd9dh0m1jm0k",
  "venue": "Nucleic Acids Research",
  "versions": []
}