{
  "abstract": "To reduce the risk associated with 3-nitropropanoic acid (3-NPA) contamination, an efficient and accurate analytical method for 3-NPA determination in sugarcane samples was established by combining magnetic solid-phase extraction (MSPE) with high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Owing to the hydrogen bonding and hydrophobic interactions, the mixed strong cation exchange (MCX) magnetic adsorbent showed effective extraction ability toward 3-NPA. Only 2 mL of organic solvent was consumed during the MSPE procedure, and the operation time was short (5 min). The limits of detection were 0.02 μg kg⁻¹ for sugarcane juice and 0.04 μg kg⁻¹ for sugarcane. The developed method showed satisfactory spiked relative recoveries (96.9-105.4%) and good precision values (RSD 1.4-9.7%). MCX-MSPE cleanup provided partial mitigation of matrix suppression, with the absolute matrix effect value rising from 39.4% to 57.1%. This study provides an efficient analytical alternative for the determination of 3-NPA in sugarcane samples.",
  "abstract_shown": true,
  "affiliations": [
    "Shanghai Pudong New Area Center for Disease Control and Prevention (Shanghai Pudong New Area Health Supervision Institute), Shanghai 200136, China.",
    "Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.",
    "School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou 450001, China.",
    "China National Center for Food Safety Risk Assessment, Beijing 100022, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yaqi Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jing Dai"
    },
    {
      "affs": [
        0
      ],
      "name": "Yijing Zhao"
    },
    {
      "affs": [
        1
      ],
      "name": "Aibo Wu"
    },
    {
      "affs": [
        2
      ],
      "name": "Lijun He",
      "orcid": "0000-0002-9209-1637"
    },
    {
      "affs": [
        0
      ],
      "name": "Lei Zheng"
    },
    {
      "affs": [
        0
      ],
      "name": "Wei Min"
    },
    {
      "affs": [
        3
      ],
      "name": "Jiang Liang"
    },
    {
      "affs": [
        1
      ],
      "name": "Na Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Lipeng Hao"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/aw221h71ysdp3.bib",
  "cited_by": 0,
  "doi": "10.3390/foods15193466",
  "fulltext_url": "https://europepmc.org/articles/PMC13664478",
  "id": "aw221h71ysdp3",
  "issns": [
    "2304-8158"
  ],
  "landing_url": "https://europepmc.org/article/MED/42883573",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1602|Analytical chemistry methods development"
    ]
  ],
  "openalex": "W7214619006",
  "pdf_url": "https://europepmc.org/articles/PMC13664478?pdf=render",
  "pmcid": "PMC13664478",
  "pmid": "42883573",
  "published": "2026-09-28",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/aw221h71ysdp3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42883573",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42883573"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1602|Analytical chemistry methods development",
      "subfield": "analytical"
    }
  ],
  "title": "Effective Extraction and Determination of 3-Nitropropanoic Acid in Sugarcane Samples Based on Magnetic Solid-Phase Extraction Coupled with HPLC-MS/MS.",
  "title_text": "Effective Extraction and Determination of 3-Nitropropanoic Acid in Sugarcane Samples Based on Magnetic Solid-Phase Extraction Coupled with HPLC-MS/MS.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/aw221h71ysdp3",
  "venue": "Foods (Basel, Switzerland)",
  "versions": []
}