{
  "abstract": "Cutaneous oncology needs to be treated locally with maximal exposure to the target with minimum systemic toxicity. Novasomes, surfactant-rich vesicles, have proven to be promising theranostic carriers for both topical and intralesional delivery. This review aims to establish a translational framework linking novasome design with theranostic-guided dosing in cutaneous oncology. A literature search of publications from the time period 2010-2026 was conducted in Scopus, PubMed, and Web of Science to capture studies on formulation, in vitro/ex vivo penetration data, in vivo efficacy, and biodistribution, and the first clinical reports; the priority was given to studies with orthogonal imaging, microdialysis, and/ or IND-relevant endpoints. The literature shows that novasomes allow improved local drug retention, controllable release kinetics, and better follicular and tumor penetration than traditional topical systems. Surface modification and deformable bilayers also help further optimise targeting, and co-loading imaging agents enables real-time visualisation, image-guided dosing, and adaptive PK/PD modelling. Advances in scalable fabrication techniques such as microfluidics and solvent-minimized processes enhance translational feasibility. However, there are still challenges in long-term stability, standardized reporting of critical quality attributes, and regulatory harmonization. In conclusion, novasomes are a pragmatic and modular platform for localized image-guided cutaneous oncology. A unique aspect of this review is the inclusion of novasome formulation strategies, theranostic functions, and concepts of PK/PD-guided dosing in a translational context for cutaneous oncology. The review bridges the gap between formulation development and clinical implementation aspects, thereby offering a practical view for future precision nanomedicine strategies.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, UP, 201308, India.",
    "Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, UP, 201308, India. rishabhamalviya19@gmail.com.",
    "Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, UP, 244001, India.",
    "College of Pharmacy, Dubai Medical University, Dubai, United Arab Emirates.",
    "RAK College of Pharmacy, RAK Medical & Health Sciences University, Ras Al Khaimah, United Arab Emirates.",
    "School of Engineering and IT, Manipal Academy of Higher Education, Dubai Campus, Dubai, United Arab Emirates. daniel.arockiam@dxb.manipal.edu."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Md Azhar"
    },
    {
      "affs": [
        1
      ],
      "name": "Rishabha Malviya"
    },
    {
      "affs": [
        2
      ],
      "name": "Phool Chandra"
    },
    {
      "affs": [
        3
      ],
      "name": "Sathvik Belagodu Sridhar"
    },
    {
      "affs": [
        4
      ],
      "name": "Javedh Shareef"
    },
    {
      "affs": [
        4
      ],
      "name": "Tarun Wadhwa"
    },
    {
      "affs": [
        5
      ],
      "name": "Daniel Arockiam"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/aw3mjbpyqgc4m.bib",
  "cited_by": 0,
  "doi": "10.1186/s13036-026-00744-8",
  "fulltext_url": "https://europepmc.org/articles/PMC13725949",
  "id": "aw3mjbpyqgc4m",
  "issns": [
    "1754-1611"
  ],
  "landing_url": "https://europepmc.org/article/MED/42972414",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "3003|Advancements in Transdermal Drug Delivery"
    ]
  ],
  "openalex": "W7172481320",
  "pdf_url": "https://europepmc.org/articles/PMC13725949?pdf=render",
  "pmcid": "PMC13725949",
  "pmid": "42972414",
  "published": "2026-08-05",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/aw3mjbpyqgc4m.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:49Z",
      "native_id": "MED:42972414",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42972414"
    },
    {
      "first_seen": "2026-11-05T12:22:23Z",
      "native_id": "PMC13725949",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s13036-026-00744-8"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3003|Advancements in Transdermal Drug Delivery",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Translational design of multifunctional novasomes for theranostic-driven precision therapy of cutaneous oncology.",
  "title_text": "Translational design of multifunctional novasomes for theranostic-driven precision therapy of cutaneous oncology.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:22:01Z",
  "url": "https://research.draconitic.com/paper/aw3mjbpyqgc4m",
  "venue": "Journal of biological engineering",
  "versions": []
}