{
  "abstract": "INTRODUCTION: Age‐related cognitive decline and Alzheimer's disease (AD) are strongly influenced by lipid metabolism, yet how central and peripheral lipid profiles relate to disease risk before symptom onset remains unclear.\n\nMETHODS: We performed comprehensive shotgun lipidomics in cerebrospinal fluid (CSF) and plasma from cognitively unimpaired older adults, with longitudinal follow‐up for Clinical Dementia Rating (CDR) conversion.\n\nRESULTS: CSF lipidomes were primarily associated with age and established CSF AD biomarkers, whereas plasma lipid profiles were strongly influenced by sex. Specific CSF phosphatidylethanolamine subspecies showed robust positive associations with CSF total tau, phosphorylated tau 181, neurogranin, and chitinase‐3 like‐1. CSF triacylglycerol TAG(C49:6), phosphatidylglycerol PG(18:0‐18:1), cholesteryl ester CE(20:3), and phosphatidylethanolamine PE(D16:0‐18:1) independently predicted CDR conversion, improving risk prediction. Plasma sphingomyelin subspecies were modestly associated with cognitive decline risk.\n\nDISCUSSION: These findings identify distinct CSF and plasma lipid signatures linked to preclinical cognitive decline and highlight brain lipid metabolism as a promising source of predictive biomarkers and therapeutic targets.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neuroscience Mayo Clinic Jacksonville Florida USA",
    "Department of Quantitative Health Sciences Mayo Clinic Jacksonville Florida USA",
    "Barshop Institute for Longevity and Aging Studies University of Texas Health Science Center at San Antonio San Antonio Texas USA",
    "Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center Washington University School of Medicine St. Louis Missouri USA",
    "Division of Biostatistics Washington University School of Medicine St. Louis Missouri USA",
    "Department of Quantitative Health Sciences Mayo Clinic Rochester Minnesota USA",
    "Department of Laboratory Medicine and Pathology Mayo Clinic Rochester Minnesota USA",
    "Departments of Structural Biology and Developmental Neurobiology St. Jude Children's Research Hospital Memphis Tennessee USA",
    "Division of Life Science and State Key Laboratory of Nervous System Disorders The Hong Kong University of Science and Technology Clear Water Bay Hong Kong China",
    "Departments of Neurology Mayo Clinic Rochester Minnesota USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 19,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Takahisa Kanekiyo"
    },
    {
      "affs": [
        1
      ],
      "name": "Launia J. White"
    },
    {
      "affs": [
        2
      ],
      "name": "Hongping Ye"
    },
    {
      "affs": [
        1
      ],
      "name": "Yingxue Ren"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Jason D. Ulrich"
    },
    {
      "affs": [
        0
      ],
      "name": "Ana‐Caroline Raulin"
    },
    {
      "affs": [
        0
      ],
      "name": "Alla Alnobani"
    },
    {
      "affs": [
        4
      ],
      "name": "Chengjie Xiong"
    },
    {
      "affs": [
        1
      ],
      "name": "Yan W. Asmann"
    },
    {
      "affs": [
        5
      ],
      "name": "Maria Vassilaki"
    },
    {
      "affs": [
        6
      ],
      "name": "Alicia Algeciras‐Schimnich"
    },
    {
      "affs": [
        7
      ],
      "name": "Junmin Peng"
    },
    {
      "affs": [
        3
      ],
      "name": "Fatima S. Amtashar"
    },
    {
      "affs": [
        3
      ],
      "name": "Suzanne E. Schindler"
    },
    {
      "affs": [
        3
      ],
      "name": "David M. Holtzman"
    },
    {
      "affs": [
        0,
        8
      ],
      "name": "Guojun Bu"
    },
    {
      "affs": [
        9
      ],
      "name": "Ronald C. Petersen"
    },
    {
      "affs": [
        1
      ],
      "name": "Michael G. Heckman"
    },
    {
      "affs": [
        2
      ],
      "name": "Xianlin Han"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/aw7gkpqa6s8ed.bib",
  "cited_by": 0,
  "doi": "10.1002/alz.71924",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13714092/",
  "id": "aw7gkpqa6s8ed",
  "issns": [
    "1552-5260",
    "1552-5279"
  ],
  "landing_url": "https://doi.org/10.1002/alz.71924",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "2738|Dementia and Cognitive Impairment Research"
    ]
  ],
  "openalex": "W7224094477",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.71924",
  "pmcid": "PMC13714092",
  "pmid": "42947286",
  "published": "2026-10-27",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/aw7gkpqa6s8ed.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:21:39Z",
      "native_id": "PMC13714092",
      "source": "pmc",
      "url": "https://doi.org/10.1002/alz.71924"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2738|Dementia and Cognitive Impairment Research",
      "subfield": "psychiatry"
    }
  ],
  "title": "CSF and plasma lipid profiling predicts risk of cognitive impairment in cognitively unimpaired older adults",
  "title_text": "CSF and plasma lipid profiling predicts risk of cognitive impairment in cognitively unimpaired older adults",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:21:39Z",
  "url": "https://research.draconitic.com/paper/aw7gkpqa6s8ed",
  "venue": "Alzheimer's & Dementia",
  "versions": []
}