{
  "abstract": "In adult neuroendocrine malignancies, including small cell lung cancer, Delta-like ligand 3 (DLL3) is a validated therapeutic target. DLL3 is expressed in neuroblastoma, a pediatric cancer of neuroendocrine origin, but subcellular localization is incompletely defined, limiting clinical translation of DLL3-targeted therapies for neuroblastoma. Methods: DLL3 expression and localization were evaluated in human neuroblastoma tumors and preclinical models using RNA sequencing, immunohistochemistry, and flow cytometry. To assess in vivo tumor accessibility, DLL3-targeted PET imaging with [89Zr]Zr-deferoxamine-SC16.56 was performed in patient-derived xenograft (PDX) models and in 4 patients with neuroblastoma. Results: DLL3 was broadly expressed across neuroblastoma tumor samples and preclinical models. Although immunohistochemistry demonstrated variable protein expression, flow cytometry revealed near-universal DLL3 cell surface localization across clinical samples and PDX models, including tumors with low expression by immunohistochemistry. DLL3-targeted PET imaging demonstrated tumor-specific uptake in PDX models and in 4 patients with relapsed neuroblastoma, confirming in vivo accessibility of DLL3. Conclusion: DLL3 overexpression in neuroblastoma is associated with targetable cell surface localization, supporting DLL3 as a clinically actionable target for imaging and therapeutic strategies.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York",
    "Department of Radiology, Molecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center, New York, New York",
    "Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, New York",
    "Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York",
    "Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York",
    "Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York",
    "Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York",
    "Radiochemistry and Molecular Imaging Probes Core, Memorial Sloan Kettering Cancer Center, New York, New York; and",
    "Department of Medicine, NYU Grossman School of Medicine, New York, New York"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 33,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Salvatore M. Aspromonte"
    },
    {
      "affs": [
        0
      ],
      "name": "Tamar Y. Feinberg"
    },
    {
      "affs": [
        1
      ],
      "name": "Somali Gavane"
    },
    {
      "affs": [
        2
      ],
      "name": "Candace Parker"
    },
    {
      "affs": [
        0
      ],
      "name": "Ali Cihan"
    },
    {
      "affs": [
        0
      ],
      "name": "Daoqi You"
    },
    {
      "affs": [
        3
      ],
      "name": "Salomon A. Tendler"
    },
    {
      "affs": [
        0
      ],
      "name": "Jaime Alvarez-Perez"
    },
    {
      "affs": [
        0
      ],
      "name": "Samantha Brosius"
    },
    {
      "affs": [
        0
      ],
      "name": "Armaan Siddiquee"
    },
    {
      "affs": [
        4
      ],
      "name": "Dylan Domenico"
    },
    {
      "affs": [
        0
      ],
      "name": "Glorymar Ibañez"
    },
    {
      "affs": [
        0
      ],
      "name": "Emily Stockfisch"
    },
    {
      "affs": [
        5
      ],
      "name": "James M. Bean"
    },
    {
      "affs": [
        0
      ],
      "name": "Anne M. Cochrane"
    },
    {
      "affs": [
        6
      ],
      "name": "Umesh Bhanot"
    },
    {
      "affs": [
        6
      ],
      "name": "Satish K. Tickoo"
    },
    {
      "affs": [
        6
      ],
      "name": "Achim Jungbluth"
    },
    {
      "affs": [
        6
      ],
      "name": "Denise Frosina"
    },
    {
      "affs": [
        0
      ],
      "name": "Paola Angelini"
    },
    {
      "affs": [
        0
      ],
      "name": "Neerav Shukla"
    },
    {
      "affs": [
        7
      ],
      "name": "Serge K. Lyashchenko"
    },
    {
      "affs": [
        8
      ],
      "name": "John T. Poirier"
    },
    {
      "affs": [
        1
      ],
      "name": "Heiko Schoder"
    },
    {
      "affs": [
        3
      ],
      "name": "Charles M. Rudin"
    },
    {
      "affs": [
        2
      ],
      "name": "Jason S. Lewis"
    },
    {
      "affs": [
        0
      ],
      "name": "Kevin J. Curran"
    },
    {
      "affs": [
        3
      ],
      "name": "Anthony Daniyan"
    },
    {
      "affs": [
        1
      ],
      "name": "Mark P. Dunphy"
    },
    {
      "affs": [
        0
      ],
      "name": "Julia L. Glade Bender"
    },
    {
      "affs": [
        0
      ],
      "name": "Shakeel Modak"
    },
    {
      "affs": [
        0
      ],
      "name": "Filemon S. Dela Cruz"
    },
    {
      "affs": [
        0
      ],
      "name": "Andrew L. Kung"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/aw8wcr8996ak0.bib",
  "cited_by": 0,
  "doi": "10.2967/jnumed.126.272770",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13724715/",
  "id": "aw8wcr8996ak0",
  "issns": [
    "0161-5505",
    "1535-5667"
  ],
  "landing_url": "https://doi.org/10.2967/jnumed.126.272770",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Translational"
    ],
    [
      "openalex",
      "2728|Neuroblastoma Research and Treatments"
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  "openalex": "W7212191338",
  "pdf_url": "https://jnm.snmjournals.org/content/jnumed/early/2026/09/10/jnumed.126.272770.full.pdf",
  "pmcid": "PMC13724715",
  "pmid": "42722443",
  "published": "2026-11-03",
  "publisher": "Society of Nuclear Medicine and Molecular Imaging",
  "ris": "https://research.draconitic.com/paper/aw8wcr8996ak0.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:23:14Z",
      "native_id": "PMC13724715",
      "source": "pmc",
      "url": "https://doi.org/10.2967/jnumed.126.272770"
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Neuroblastoma Research and Treatments",
      "subfield": "neurology"
    }
  ],
  "title": "Cell Surface Expression and PET Imaging Establish DLL3 as a Clinically Actionable Target in Neuroblastoma",
  "title_text": "Cell Surface Expression and PET Imaging Establish DLL3 as a Clinically Actionable Target in Neuroblastoma",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:07Z",
  "url": "https://research.draconitic.com/paper/aw8wcr8996ak0",
  "venue": "Journal of Nuclear Medicine",
  "versions": []
}