{
  "abstract": "Secreted proteins are essential to modulate homeostasis in the extracellular space and facilitate communication to distal cells or tissues. Yet, the identity and functional importance of extracellular proteins in aging have been understudied. Here we use proximity labeling followed by quantitative proteomics to systematically characterize proteins along the intestinal secretory pathway in C. elegans, focusing on secreted proteins. We identify intestine-secreted proteins that are modulated with age, and validate the secretion of these proteins in vivo. One of these secreted proteins, ACP7, is well conserved in humans, and its overexpression extends lifespan in a secretion-dependent manner. Interestingly, we find that ACP7 acts as a secreted phosphatase in the extracellular space. Finally, we identify additional proteins along the secretory pathway that regulate lifespan. Our systematic characterization of tissue-specific secreted proteins during aging uncovers conserved proteins that impact lifespan and highlights extracellular enzymes associated with lifespan regulation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Genetics, Stanford University, Stanford, CA, USA",
    "Present address: Institute of Molecular Biology (IMB), Mainz, Germany",
    "Biomedical Informatics Graduate Program, Stanford University, Stanford, CA, USA",
    "Stanford Biophysics Graduate Program, Stanford University, Stanford, CA, USA",
    "Arc Institute, Palo Alto, CA 94304, USA",
    "Department of Chemical Engineering, Stanford University, Stanford, CA, USA",
    "The Institute for Chemistry, Engineering & Medicine for Human Health, Stanford University, Stanford, CA, USA",
    "Present address: Arc Institute, Palo Alto, CA 94304, USA",
    "Biohub, San Francisco, CA, USA",
    "Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA",
    "Stanford Medical Scientist Training Program, Stanford University, Stanford, CA, USA",
    "Glenn Center for the Biology of Aging, Stanford University, Stanford, CA, USA",
    "Wu Tsai Institute of Neurosciences, Stanford University, Stanford, CA, USA",
    "Lead contact"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jason W. Miklas"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Katharina Papsdorf"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Eric D. Sun"
    },
    {
      "affs": [
        0
      ],
      "name": "Aleksandra Tsenter"
    },
    {
      "affs": [
        0
      ],
      "name": "Nicole R. Haseley"
    },
    {
      "affs": [
        0,
        3,
        4
      ],
      "name": "Brandon Ameglio"
    },
    {
      "affs": [
        0,
        5,
        6,
        7
      ],
      "name": "Uche N. Medoh"
    },
    {
      "affs": [
        0
      ],
      "name": "Daniel Richard"
    },
    {
      "affs": [
        8
      ],
      "name": "Frank McCarthy"
    },
    {
      "affs": [
        9
      ],
      "name": "Karen L. Artiles"
    },
    {
      "affs": [
        0,
        5,
        6
      ],
      "name": "Andy Hims"
    },
    {
      "affs": [
        0,
        5,
        6
      ],
      "name": "Aleksandra Levina"
    },
    {
      "affs": [
        0,
        3,
        10
      ],
      "name": "Olivia Y. Zhou"
    },
    {
      "affs": [
        8
      ],
      "name": "Joshua E. Elias"
    },
    {
      "affs": [
        0,
        5,
        6
      ],
      "name": "Monther Abu-Remaileh"
    },
    {
      "affs": [
        0,
        11,
        12,
        13
      ],
      "name": "Anne Brunet"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/axrb1hh3zvkj4.bib",
  "cited_by": 0,
  "doi": "10.1016/j.celrep.2026.117902",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13714676/",
  "id": "axrb1hh3zvkj4",
  "issns": [
    "2211-1247"
  ],
  "landing_url": "https://doi.org/10.1016/j.celrep.2026.117902",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "1302|Genetics, Aging, and Longevity in Model Organisms"
    ]
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  "openalex": "W7204492565",
  "pdf_url": null,
  "pmcid": "PMC13714676",
  "pmid": "42658673",
  "published": "2026-08-27",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/axrb1hh3zvkj4.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:22:07Z",
      "native_id": "PMC13714676",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.celrep.2026.117902"
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  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1302|Genetics, Aging, and Longevity in Model Organisms",
      "subfield": "cell-biology"
    }
  ],
  "title": "An in vivo resource of age-regulated C. elegans intestinal secretory-pathway proteins highlights secreted enzymes associated with lifespan regulation",
  "title_text": "An in vivo resource of age-regulated C. elegans intestinal secretory-pathway proteins highlights secreted enzymes associated with lifespan regulation",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:22:07Z",
  "url": "https://research.draconitic.com/paper/axrb1hh3zvkj4",
  "venue": "Cell reports",
  "versions": []
}