{
  "abstract": "Background: Stroke is one of the leading causes of death among Chinese residents, and air pollution is a significant environmental risk factor. Currently, research on the association between air pollution and stroke incidence remains limited in low-pollution karst cities in Southwest China. This study aims to evaluate the short-term effects of major air pollutants on stroke incidence in Guiyang City.\n\nMethods: Daily data on stroke incidence, air pollutants, and meteorological conditions for permanent residents of Guiyang from 2016 to 2021 were collected. A time-series analysis was conducted using a generalized additive model (GAM) based on a quasi-Poisson distribution. Long-term trends, meteorological factors, day-of-week effects, and holiday effects were controlled. The relative risk ( RR ) and 95% CI for stroke incidence per 10 μg/m ³ increase in pollutant concentration (CO: 1 mg/m ³ ) were assessed. Single-day and cumulative lag models were used to examine lag effects, and analyses were stratified by gender and age.\n\nResults: A total of 11,517 stroke cases were reported, with a daily average of 5.25 cases. Short-term exposure to PM₂.₅, PM₁₀, SO₂, NO₂, and O₃ (per 10 μg/m ³ increase) and CO (per 1 mg/m ³ increase) was positively associated with stroke risk. The RRs (95% CI ) at maximum lag were: PM₂.₅ 1.026 (1.005–1.048), PM₁₀ 1.015 (1.001–1.030), SO₂ 1.075 (1.016–1.137), NO₂ 1.057 (1.017–1.098), O₃ 1.013 (1.003–1.023), and CO 1.346 (1.072–1.691). Women were more sensitive to all six pollutants, especially CO (lag0 RR = 1.548, 95% CI : 1.116–2.147). Older adults (≥65 years) showed increased risk across all pollutants, while only NO₂ and PM₁₀ had statistically significant effects on those <65 years.\n\nConclusion: Even under low pollution levels, short-term exposure to air pollutants is significantly associated with increased stroke risk with a lag effect, particularly among women and older adults. Strengthening air quality management and protection for high-risk populations is recommended to potentially reduce the burden of stroke.",
  "abstract_shown": true,
  "affiliations": [
    "School of Basic Medicine, Guizhou University of Traditional Chinese Medicine",
    "Guizhou Center for Disease Control and Prevention",
    "Guiyang Municipal Center for Disease Control and Prevention"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ling Zhang"
    },
    {
      "affs": [
        1
      ],
      "name": "Minmin Su"
    },
    {
      "affs": [
        0
      ],
      "name": "Shuangfei Zhai"
    },
    {
      "affs": [
        2
      ],
      "name": "Meiqin Jiang"
    },
    {
      "affs": [
        1
      ],
      "name": "Xuanhao Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Ruifang Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Gang Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Jianhua Zhang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/axzjvw2gh8w2a.bib",
  "cited_by": 0,
  "doi": "10.3389/fpubh.2026.1777772",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13719484/?tool=EBI",
  "id": "axzjvw2gh8w2a",
  "issns": [
    "2296-2565"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fpubh.2026.1777772/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2307|Air Quality and Health Impacts"
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  "openalex": "W7222620610",
  "pdf_url": "https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2026.1777772/pdf",
  "pmcid": "PMC13719484",
  "pmid": "42964290",
  "published": "2026-10-16",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/axzjvw2gh8w2a.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:22Z",
      "native_id": "10.3389/fpubh.2026.1777772",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fpubh.2026.1777772/full"
    },
    {
      "first_seen": "2026-10-31T12:21:36Z",
      "native_id": "PMC:PMC13719484",
      "source": "europepmc",
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2307|Air Quality and Health Impacts",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Time-series analysis of the impact of short-term exposure to atmospheric pollutants on stroke risk among residents in Guiyang City, 2016–2021",
  "title_text": "Time-series analysis of the impact of short-term exposure to atmospheric pollutants on stroke risk among residents in Guiyang City, 2016–2021",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:20:32Z",
  "url": "https://research.draconitic.com/paper/axzjvw2gh8w2a",
  "venue": "Frontiers in Public Health",
  "versions": []
}