{
  "abstract": "Purpose: Advances in neonatal care have improved the survival of very preterm infants, but neurodevelopment remains a concern. This study aimed to investigate whether neonatal gastrointestinal (GI) surgery independently contributes to adverse neurodevelopmental outcomes in such infants, distinct from the underlying illness severity.\n\nMaterials and Methods: In this retrospective cohort study (2011–2023) of infants born at <32 weeks’ gestation, propensity score matching (1:2) yielded 32 surgical and 66 non-surgical infants. Neurodevelopment was assessed using Bayley Scales of Infant and Toddler Development (BSID) II or III at 6–12 and 18–24 months’ corrected age. Brain magnetic resonance images (MRIs) at term-equivalent age (TEA) were analyzed for gross structural abnormalities and white matter injury (WMI).\n\nResults: The surgery group demonstrated a higher rate of gross structural abnormality (31.3% vs. 9.1%, p=0.005) and a numerically higher proportion of moderate WMI (18.7% vs. 6.1%, p=0.079) on TEA-MRI. Neurodevelopmental assessments revealed that the surgery group had lower BSID scores and a higher prevalence of severe impairment (scores <70) in both cognitive and motor domains at all follow-up points (all p<0.05). Multivariable logistic regression identified neonatal GI surgery as being independently associated with severe cognitive delay [adjusted odds ratio (aOR): 11.16, 95% confidence interval (CI): 1.81–68.68] and severe motor delay (aOR: 10.72, 95% CI: 2.13–53.99) at 18–24 months.\n\nConclusion: Very preterm infants requiring neonatal GI surgery represent a high-risk population for adverse neurodevelopmental outcomes, even after accounting for prematurity and major comorbidities. Long-term neurodevelopmental surveillance and early intervention are warranted in this vulnerable group.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Neonatology, Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea .",
    "Division of Pediatric Surgery, Department of Surgery, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea ."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Joo Hi Kim",
      "orcid": "0000-0002-2025-5268"
    },
    {
      "affs": [
        0
      ],
      "name": "Sungbo Shim",
      "orcid": "0000-0001-9703-7050"
    },
    {
      "affs": [
        0
      ],
      "name": "Ching-yu Lin",
      "orcid": "0009-0008-5530-637X"
    },
    {
      "affs": [
        0
      ],
      "name": "Yoonmi Jeong",
      "orcid": "0009-0008-5097-5224"
    },
    {
      "affs": [
        0
      ],
      "name": "Sumin Lee",
      "orcid": "0000-0001-8777-425X"
    },
    {
      "affs": [
        0
      ],
      "name": "Seung Hwan Baek",
      "orcid": "0000-0002-7890-6916"
    },
    {
      "affs": [
        0
      ],
      "name": "Jungho Han",
      "orcid": "0000-0001-6661-8127"
    },
    {
      "affs": [
        0
      ],
      "name": "Hoseon Eun",
      "orcid": "0000-0001-7212-0341"
    },
    {
      "affs": [
        0
      ],
      "name": "Min Soo Park",
      "orcid": "0000-0002-4395-9938"
    },
    {
      "affs": [
        1
      ],
      "name": "In Geol Ho",
      "orcid": "0000-0003-4195-871X"
    },
    {
      "affs": [
        0
      ],
      "name": "Jeong Eun Shin",
      "orcid": "0000-0002-4376-8541"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ay3eggetmz398.bib",
  "cited_by": 0,
  "doi": "10.3349/ymj.2026.0399",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13713182/",
  "id": "ay3eggetmz398",
  "issns": [
    "0513-5796",
    "1976-2437"
  ],
  "landing_url": "https://doi.org/10.3349/ymj.2026.0399",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "heading",
      "Pediatrics"
    ],
    [
      "openalex",
      "2735|Infant Development and Preterm Care"
    ]
  ],
  "openalex": "W7212552632",
  "pdf_url": "http://eymj.org/Synapse/Data/PDFData/0069YMJ/ymj-67-e62.pdf",
  "pmcid": "PMC13713182",
  "pmid": "42937143",
  "published": "2026-09-08",
  "publisher": "Yonsei University College of Medicine",
  "ris": "https://research.draconitic.com/paper/ay3eggetmz398.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:23:34Z",
      "native_id": "PMC13713182",
      "source": "pmc",
      "url": "https://doi.org/10.3349/ymj.2026.0399"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "heading:Pediatrics",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Neurodevelopmental Outcomes of Very Preterm Infants Who Underwent Neonatal Gastrointestinal Surgery: A Single-Center Retrospective Cohort Study",
  "title_text": "Neurodevelopmental Outcomes of Very Preterm Infants Who Underwent Neonatal Gastrointestinal Surgery: A Single-Center Retrospective Cohort Study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:17Z",
  "url": "https://research.draconitic.com/paper/ay3eggetmz398",
  "venue": "Yonsei Medical Journal",
  "versions": []
}