{
  "abstract": "Diabetic foot ulcers (DFUs) present a major clinical challenge because of persistent hyperglycemia, hypoxia, impaired angiogenesis, and chronic inflammation. Conventional dressings have limited capacity to modulate these pathological processes. Here, we report a glucose/pH dual-responsive hydrogel, denoted CBOD, constructed through a dynamic covalent network comprising Schiff base and boronate ester bonds between phenylboronic acid-grafted chitosan (CS-BA) and dopamine-modified oxidized sodium alginate (OSA-DA). Copper peroxide (CuO₂) nanoparticles are encapsulated within this network to form CuO₂/CBOD. Under acidic (pH 5.5) and high-glucose conditions, competitive binding and bond hydrolysis promote network relaxation, facilitating the stimuli-dependent release of oxygen and copper ions. In vitro assessments demonstrate good cytocompatibility and enhanced migration and tube formation of human umbilical vein endothelial cells (HUVECs). In a diabetic rat model of full-thickness excisional wounds, the hydrogel accelerates wound closure, with closure approaching 100% by day 14. Treatment is associated with reduced expression of the M1-associated markers interleukin-1β (IL-1β) and cluster of differentiation 80 (CD80), increased expression of the M2-associated markers interleukin-10 (IL-10) and cluster of differentiation 163 (CD163), and enhanced expression of the vascular markers cluster of differentiation 31 (CD31) and alpha-smooth muscle actin (α-SMA). These findings support the potential of CuO₂/CBOD as a multifunctional dressing for diabetic wound management.",
  "abstract_shown": true,
  "affiliations": [
    "College of Chemistry and Materials Science, Engineering Research Center of Artificial Organs and Materials, Jinan University, Guangzhou 510632, China.",
    "School of Medicine, Foshan University, Foshan 528225, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Lanqin Yu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiang Jia"
    },
    {
      "affs": [
        0
      ],
      "name": "Lejia Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaojun Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Na Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Lihua Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Yifan Zhang",
      "orcid": "0009-0009-1904-2490"
    },
    {
      "affs": [
        0
      ],
      "name": "Changren Zhou"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ay69d2jwgeyjn.bib",
  "cited_by": 0,
  "doi": "10.3390/gels12100864",
  "fulltext_url": "https://europepmc.org/articles/PMC13704670",
  "id": "ay69d2jwgeyjn",
  "issns": [
    "2310-2861"
  ],
  "landing_url": "https://europepmc.org/article/MED/42929899",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2742|Wound Healing and Treatments"
    ]
  ],
  "openalex": "W7214148074",
  "pdf_url": "https://europepmc.org/articles/PMC13704670?pdf=render",
  "pmcid": "PMC13704670",
  "pmid": "42929899",
  "published": "2026-09-24",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/ay69d2jwgeyjn.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:01Z",
      "native_id": "MED:42929899",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42929899"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2742|Wound Healing and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Copper Peroxide-Loaded Dual-Responsive Hydrogel for Enhanced Diabetic Wound Healing Through Oxygen Release and Promotion of Angiogenesis.",
  "title_text": "Copper Peroxide-Loaded Dual-Responsive Hydrogel for Enhanced Diabetic Wound Healing Through Oxygen Release and Promotion of Angiogenesis.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:01Z",
  "url": "https://research.draconitic.com/paper/ay69d2jwgeyjn",
  "venue": "Gels (Basel, Switzerland)",
  "versions": []
}