{
  "abstract": "Borophene (BPH), a monolayer boron allotrope, exhibits outstanding electrical and mechanical properties but remains intrinsically constrained by its excessive susceptibility to oxidative degradation in aqueous and physiological environments. This study demonstrates that protein-assisted exfoliation using human serum albumin (HSA) establishes a dynamic biointerfacial sheath (BIS) that decouples environmental stability from intracellular degradation. HSA forms a robust BIS via multivalent hydrophobic, electrostatic, and thiol-mediated interactions, driving exfoliation into ultrathin nanosheets while suppressing air- and serum-induced oxidation. Proteinized BPH (PBPH) shows enhanced extracellular colloidal and chemical stability; however, upon cellular uptake, the same interface promotes rapid reactive oxygen species-driven degradation, leading to lattice fragmentation, loss of crystallinity, and conversion into soluble boronate species. Multimodal analyses confirm accelerated degradation kinetics and environmental stability of PBPH. These results highlight the protein corona as an active regulator of nanomaterial fate, enabling programmable decoupling of extracellular persistence from intracellular clearance in oxidation-prone two-dimensional systems.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Nuclear Engineering, The Pennsylvania State University, University Park, Pennsylvania16802, United States.",
    "Huck Institutes of the Life Sciences, 101 Huck Life Sciences Building, University Park, Pennsylvania16802, United States.",
    "Department of Biomedical Engineering, The Pennsylvania State University, University Park, Pennsylvania16802, United States.",
    "Department of Bioengineering, Institute of Natural Sciences, Ege University, Izmir35100, Türkiye.",
    "Department of Materials Science and Engineering, The Pennsylvania State University, University Park, Pennsylvania16802, United States.",
    "Surface Analysis Facility, University of Delaware, Newark, Delaware19716, United States.",
    "Tomocube Inc., San Diego, California92108, United States.",
    "Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania16802, United States.",
    "Materials Research Institute, The Pennsylvania State University, University Park, Pennsylvania16802, United States.",
    "Center for Infectious Disease Dynamics, The Pennsylvania State University, University Park, Pennsylvania16802, United States."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Pranay Saha",
      "orcid": "0000-0003-3915-8182"
    },
    {
      "affs": [
        2
      ],
      "name": "Shraddha Krishnakumar"
    },
    {
      "affs": [
        0
      ],
      "name": "Teresa Aditya",
      "orcid": "0000-0002-7829-9837"
    },
    {
      "affs": [
        0
      ],
      "name": "Nada Maher"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Aysenur Yardim",
      "orcid": "0000-0003-4762-7292"
    },
    {
      "affs": [
        0
      ],
      "name": "Oguzhan Colak"
    },
    {
      "affs": [
        4
      ],
      "name": "David Skrodzki",
      "orcid": "0000-0003-2838-6446"
    },
    {
      "affs": [
        1
      ],
      "name": "Sung Hyun Cho"
    },
    {
      "affs": [
        5
      ],
      "name": "Xu Feng"
    },
    {
      "affs": [
        6
      ],
      "name": "Dongjun Shin"
    },
    {
      "affs": [
        0,
        1,
        2,
        4,
        7,
        8,
        9
      ],
      "name": "Dipanjan Pan",
      "orcid": "0000-0003-0175-4704"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/aybp8hv917scc.bib",
  "cited_by": 1,
  "doi": "10.1021/acsnano.6c11186",
  "fulltext_url": "https://europepmc.org/articles/PMC13602918",
  "id": "aybp8hv917scc",
  "issns": [
    "1936-0851",
    "1936-086X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42916092",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2505|Boron and Carbon Nanomaterials Research"
    ]
  ],
  "openalex": "W7212035371",
  "pdf_url": "https://europepmc.org/articles/PMC13602918?pdf=render",
  "pmcid": "PMC13602918",
  "pmid": "42916092",
  "published": "2026-09-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/aybp8hv917scc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:02Z",
      "native_id": "MED:42916092",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42916092"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2505|Boron and Carbon Nanomaterials Research",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Proteinized Surface Remodeling Decouples Environmental Stability from Intracellular Degradation in Oxidation-Prone 2D Nanoborophene.",
  "title_text": "Proteinized Surface Remodeling Decouples Environmental Stability from Intracellular Degradation in Oxidation-Prone 2D Nanoborophene.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:02Z",
  "url": "https://research.draconitic.com/paper/aybp8hv917scc",
  "venue": "ACS nano",
  "versions": []
}