{
  "abstract": "There is limited evidence on the advantages of brain 2-deoxy-2-[ ¹⁸ F]fluoroglucose (FDG) positron emission tomography (PET) with simultaneous magnetic resonance imaging (PET-MR) over PET with computed tomography (PET/CT). We quantitatively compared brain FDG PET/CT and PET-MR images from a large clinical cohort. Participants with refractory epilepsy or cognitive problems underwent PET/CT at approximately 30 min post-injection, followed by PET-MR at approximately 100 min. Standardized uptake values (SUVs) were extracted in anatomical regions using a multi-atlas method, and voxel-wise comparisons were performed with statistical parametric mapping. Fifty-five image pairs passed quality control. Within-subject correlations between modalities were very high (0.96, range 0.84–0.99); within-region, across-participant correlations were 0.82 (0.72–0.90). PET-MR SUVs were on average 20% higher than PET/CT, more so for higher-uptake regions. Voxel-wise, PET-MR showed relatively higher uptake in visual and auditory cortices, lower uptake in medial frontal and anteromesial temporal cortices, and better grey-white matter contrast. We found a very close correspondence between the two modalities with their respective attenuation correction methods and sensory activation between scans; the different uptake times explain differences in absolute SUV levels and grey-white matter contrast. With awareness of these differences, brain PET-MR can be used clinically.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Arick Sagel Martinez"
    },
    {
      "name": "Anthime Flaus",
      "orcid": "0000-0001-5877-2159"
    },
    {
      "name": "Rolf A. Heckemann",
      "orcid": "0000-0003-3582-3683"
    },
    {
      "name": "Joel Dunn",
      "orcid": "0000-0002-0936-9993"
    },
    {
      "name": "Sufian Al-Ethawi"
    },
    {
      "name": "Sami Jeljeli"
    },
    {
      "name": "Colm J. McGinnity",
      "orcid": "0000-0002-2692-918X"
    },
    {
      "name": "Alexander Hammers",
      "orcid": "0000-0001-9530-4848"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/aycem0m9pjhm6.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-72030-y",
  "fulltext_url": null,
  "id": "aycem0m9pjhm6",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://www.nature.com/articles/s41598-026-72030-y",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2741|Medical Imaging Techniques and Applications"
    ]
  ],
  "openalex": "W7223925844",
  "pdf_url": "https://www.nature.com/articles/s41598-026-72030-y_reference.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-27",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/aycem0m9pjhm6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:34Z",
      "native_id": "10.1038/s41598-026-72030-y",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41598-026-72030-y"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2741|Medical Imaging Techniques and Applications",
      "subfield": "imaging"
    }
  ],
  "title": "[18F]FDG brain PET-MR versus PET/CT in a clinical cohort: intra-subject quantitative comparisons",
  "title_text": "[18F]FDG brain PET-MR versus PET/CT in a clinical cohort: intra-subject quantitative comparisons",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:34Z",
  "url": "https://research.draconitic.com/paper/aycem0m9pjhm6",
  "venue": "Scientific Reports",
  "versions": []
}