{
  "abstract": "Mesenchymal stem cells (MSCs) have shown therapeutic potential for osteoarthritis (OA), but their clinical application is limited by the need for extensive ex vivo expansion. Human umbilical cord MSC‐derived exosomes (hUCMSC‐Exos) have emerged as a promising cell‐free alternative because of their cartilage‐protective and immunomodulatory properties. hUCMSC‐Exos were characterized by nanoparticle tracking analysis and evaluated in an interleukin‐1β (IL‐1β)‐stimulated human chondrocyte model and an anterior cruciate ligament transection (ACLT)‐induced rat OA model. In vitro, hUCMSC‐Exos suppressed inflammatory and catabolic responses while enhancing extracellular matrix synthesis, as evidenced by reduced IL‐1β, MMP13, and Type X collagen expression and increased TIMP1, aggrecan, and Type II collagen expression. In vivo, repeated intra‐articular administration of hUCMSC‐Exos attenuated cartilage degeneration, resulting in improved gross joint morphology, reduced histopathological damage, increased glycosaminoglycan deposition and Type II collagen expression, and decreased MMP13 expression. These structural improvements were accompanied by enhanced functional recovery, as demonstrated by improved hind limb weight‐bearing and treadmill running endurance. These findings suggest that hUCMSC‐Exos alleviate cartilage degeneration and improve joint function, supporting their potential as a promising cell‐free therapeutic approach for OA.",
  "abstract_shown": true,
  "affiliations": [
    "Orthopaedic Research Center Kaohsiung Medical University Kaohsiung Taiwan",
    "Regenerative Medicine and Cell Therapy Research Center Kaohsiung Medical University Kaohsiung Taiwan",
    "Department of Orthopaedics, Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan",
    "Department of Orthopedics Kaohsiung Medical University Gangshan Hospital Kaohsiung Taiwan",
    "Department of Orthopedics, School of Post‐Baccalaureate Medicine, College of Medicine Kaohsiung Medical University Kaohsiung Taiwan",
    "Department of Orthopaedic Surgery University of Virginia Charlottesville Virginia USA",
    "ExoOne Bio Co., Ltd. Taipei Taiwan",
    "School of Medicine, College of Medicine Kaohsiung Medical University Kaohsiung Taiwan",
    "Ph.D. Program in Biomedical Engineering, College of Medicine Kaohsiung Medical University Kaohsiung Taiwan",
    "Department of Materials Engineering, College of Engineering National Pingtung University of Science and Technology Pingtung Taiwan",
    "Department of Pediatrics, Division of Infectious Diseases Chang Gung Memorial Hospital Taoyuan Taiwan",
    "College of Public Health Taipei Medical University Taipei Taiwan"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0,
        1,
        2,
        3,
        4
      ],
      "name": "Sung‐Yen Lin",
      "orcid": "0000-0002-4191-2183"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yi‐Shan Lin",
      "orcid": "0009-0006-1604-0914"
    },
    {
      "affs": [
        0,
        1,
        5
      ],
      "name": "Shu‐Chun Chuang",
      "orcid": "0000-0002-3590-7775"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Yi‐Wen Kuo",
      "orcid": "0009-0008-7521-8641"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Cheng‐Jung Ho",
      "orcid": "0000-0002-9049-3675"
    },
    {
      "affs": [
        6
      ],
      "name": "Kai‐Hsuan Wang",
      "orcid": "0009-0000-4090-6091"
    },
    {
      "affs": [
        6
      ],
      "name": "Wei‐Cheng Tsai",
      "orcid": "0009-0006-8481-386X"
    },
    {
      "affs": [
        6
      ],
      "name": "Zhi‐Xiang Li",
      "orcid": "0009-0003-7495-0332"
    },
    {
      "affs": [
        6
      ],
      "name": "Wan‐Jung Lin",
      "orcid": "0009-0005-0575-7875"
    },
    {
      "affs": [
        6
      ],
      "name": "Yi‐Ju Hsieh",
      "orcid": "0009-0004-1217-8049"
    },
    {
      "affs": [
        0,
        1,
        2,
        7,
        8,
        9
      ],
      "name": "Chung‐Hwan Chen",
      "orcid": "0000-0001-8941-4792"
    },
    {
      "affs": [
        10,
        11
      ],
      "name": "Tzou‐Yien Lin",
      "orcid": "0000-0002-6175-2471"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ayhsxhgekmj46.bib",
  "cited_by": 0,
  "doi": "10.1002/kjm2.70312",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13735434/",
  "id": "ayhsxhgekmj46",
  "issns": [
    "1607-551X",
    "2410-8650"
  ],
  "landing_url": "https://doi.org/10.1002/kjm2.70312",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2745|Osteoarthritis Treatment and Mechanisms"
    ]
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  "openalex": "W7225332915",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/kjm2.70312",
  "pmcid": "PMC13735434",
  "pmid": "42985799",
  "published": "2026-11-05",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/ayhsxhgekmj46.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:21:07Z",
      "native_id": "PMC13735434",
      "source": "pmc",
      "url": "https://doi.org/10.1002/kjm2.70312"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2745|Osteoarthritis Treatment and Mechanisms",
      "subfield": "general"
    }
  ],
  "title": "Human Umbilical Cord Mesenchymal Stem Cell‐Derived Exosomes Preserve Cartilage Homeostasis and Restore Joint Function in Experimental Osteoarthritis",
  "title_text": "Human Umbilical Cord Mesenchymal Stem Cell‐Derived Exosomes Preserve Cartilage Homeostasis and Restore Joint Function in Experimental Osteoarthritis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:21:07Z",
  "url": "https://research.draconitic.com/paper/ayhsxhgekmj46",
  "venue": "The Kaohsiung Journal of Medical Sciences",
  "versions": []
}