{
  "abstract": "Introduction: Sickle cell anemia (SCA) is characterized by chronic inflammation and increased metabolic demand, making nutritional assessment essential. Total fat intake, particularly saturated fat, may worsen inflammation and influence nutritional status and clinical outcomes. Objective: To analyze the impact of total fat intake on the clinical condition of patients with sickle cell anemia treated at the Amazonas Hematology and Hemotherapy Hospital Foundation (FHEMOAM). Material and Method: A cross-sectional quantitative descriptive study was conducted with a sample of 77 patients diagnosed with sickle cell anemia. The dietary intake of the subjects was meticulously documented using a 24-hour dietary recall method and subsequently analyzed in accordance with the Acceptable Macronutrient Distribution Range (AMDR). Results: The mean total cholesterol (TC) consumption of subjects in the study was found to be less than 200 mg, with this being observed in 47.4% of children, 33.3% of adolescents, and 41.9% of adults. (p=0.61). Across all age groups, the consumption of saturated fat surpassed 7% of the total energy value, reaching 94.7% in children, 96.3% in adolescents, and 100% in adults (p=0.51). The consumption of polyunsaturated fat at levels below 10% was observed to be more prevalent among adolescents (62.9%), children (57.9%), and adults (54.8%) (p=0.38). Conversely, the ingestion of more than 20% of monosaturated fat exhibited substantial disparities (p=0.06) with respect to age group, manifesting in children (15.8%), adolescents (40.7%), and adults (48.3%). As anticipated, the linear regression analysis indicated a correlation between saturated fat intake and elevated BMI (OR=1.652; p=0.007). Conversely, monounsaturated fat intake exhibited a substantial negative correlation (OR=0.664; p=0.018), suggesting a potential protective effect against weight gain. Discussion: The observed consumption patterns of total fat among the patient population reflect characteristics that are consistent with the traditional Brazilian diet. Total cholesterol levels below 200 mg/dL may be indicative of a degree of nutritional awareness or natural limitations associated with the clinical condition. Conversely, the most concerning finding was high saturated fat intake ‒ exceeding 7% of total energy intake ‒ as it is directly linked to comorbidities that pose risks in sickle cell anemia. In children, a polyunsaturated fat intake of less than 10% may indicate an inadequate intake of fatty acid sources, which are imperative for immune function and the modulation of inflammation ‒ critical factors for patients with sickle cell anemia. Conclusion: The findings of this research underscore the necessity for targeted nutritional interventions, underscoring the significance of dietary guidance, dietary re-education, and nutritional counseling in the management of these patients. This study underscores the significance of incorporating dietary patterns and the process of aging as pivotal components in the nutritional management of adults afflicted with sickle cell disease. This underscores the necessity for strategies that promote a diet consisting of healthy fats and high-quality proteins, in conjunction with the limitation of ultra-processed foods and those with high saturated fat content.",
  "abstract_shown": true,
  "affiliations": [
    "Programa de Pós-Graduação em História da Universidade do Estado do Amazonas (PPGH/UEA), Manaus, AM, Brazil",
    "Programa de Pós-Graduação em Farmácia (PPGFAR) da Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil",
    "Programa de Pós-Graduação Stricto Sensu em Imunologia Básica e Aplicada da Universidade Federal do Amazonas (PPGIBA/UFAM), Manaus, AM, Brazil"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Gracineide Pereira DA SILVA"
    },
    {
      "affs": [
        0
      ],
      "name": "George Allan VILLAROUCO SILVA"
    },
    {
      "affs": [
        0
      ],
      "name": "Nelson Abrahim FRAIJI"
    },
    {
      "affs": [
        1
      ],
      "name": "Renato Santos LEAL"
    },
    {
      "affs": [
        2
      ],
      "name": "Rajendranath RAMASAWMY"
    },
    {
      "name": "José Pereira MOURA NETO"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ayjsxb8t705xx.bib",
  "cited_by": 0,
  "doi": "10.1016/j.htct.2026.106579",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S2531137926003263",
  "id": "ayjsxb8t705xx",
  "issns": [
    "2531-1379",
    "2531-1387"
  ],
  "landing_url": "https://doi.org/10.1016/j.htct.2026.106579",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC633-647.5"
    ],
    [
      "openalex",
      "2716|Hemoglobinopathies and Related Disorders"
    ]
  ],
  "openalex": "W7223154878",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-23",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/ayjsxb8t705xx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:43:20Z",
      "native_id": "991549e6e34549229d8a05218fb74ca9",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.htct.2026.106579"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2716|Hemoglobinopathies and Related Disorders",
      "subfield": "human-genetics"
    }
  ],
  "title": "INFLUENCE OF TOTAL FAT INTAKE ON THE NUTRITIONAL STATUS OF CHILDREN, ADOLESCENTS AND ADULTS WITH SICKLE CELL ANEMIA",
  "title_text": "INFLUENCE OF TOTAL FAT INTAKE ON THE NUTRITIONAL STATUS OF CHILDREN, ADOLESCENTS AND ADULTS WITH SICKLE CELL ANEMIA",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:43:20Z",
  "url": "https://research.draconitic.com/paper/ayjsxb8t705xx",
  "venue": "Hematology, Transfusion and Cell Therapy",
  "versions": []
}