{
  "abstract": "Sex differences in melanoma incidence and mortality are well-established. Previous work has shown that the female survival advantage can be largely explained by differences in clinico-pathologic features, such as age, Breslow thickness, ulceration, mitoses, and primary site. Here we test the hypothesis that sex-differentiated expression of micro-RNAs (miRNAs) may be associated with sex differences in melanoma pathology. In a sample of 715 AJCC stage II/III primary melanomas from the InterMEL project, we find two miRNAs (miR-361 and miR-4286) that are differentially expressed in males and females, and further find one of these (miR-4286) to be associated with both greater Breslow thickness and the presence of brisk tumor infiltrating lymphocytes (TILs). These results suggest that miR-4286 may be a candidate marker for sex differences in melanoma pathology. Functional experiments may confirm whether this relationship is causal or purely associative.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Internal Medicine and UNM Comprehensive Cancer Center, University of New Mexico"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "A. Z. Reynolds"
    },
    {
      "name": "D. L. Corcoran"
    },
    {
      "name": "L. Luo"
    },
    {
      "name": "K. J. Busam"
    },
    {
      "name": "C. Lezcano"
    },
    {
      "name": "C. Amos"
    },
    {
      "name": "D. Argibay"
    },
    {
      "name": "R. Shen"
    },
    {
      "name": "C. B. Begg"
    },
    {
      "name": "N. E. Thomas"
    },
    {
      "name": "I. Orlow"
    },
    {
      "name": "E. Hernando"
    },
    {
      "name": "M. Berwick"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/aymmamrwpdm01.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.04.26362289",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.09.04.26362289v1.full",
  "id": "aymmamrwpdm01",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.09.04.26362289v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "oncology"
    ],
    [
      "openalex",
      "2730|Cutaneous Melanoma Detection and Management"
    ]
  ],
  "openalex": "W7212251923",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.09.04.26362289v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-04",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/aymmamrwpdm01.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:16Z",
      "native_id": "10.64898/2026.09.04.26362289",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.09.04.26362289v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:oncology",
      "subfield": "oncology"
    }
  ],
  "title": "Sex-associated miR-4286 is related to Breslow thickness and TILs in stage II/III primary cutaneous melanoma",
  "title_text": "Sex-associated miR-4286 is related to Breslow thickness and TILs in stage II/III primary cutaneous melanoma",
  "type": "preprint",
  "updated_at": "2026-10-30T12:18:16Z",
  "url": "https://research.draconitic.com/paper/aymmamrwpdm01",
  "venue": "medRxiv",
  "versions": []
}