{
  "abstract": "Background:: Heart failure (HF) remains a major cause of cardiovascular mortality worldwide, imposing a substantial burden on healthcare systems. Although physical exercise is known to exert cardioprotective effects, its underlying mechanisms are not fully understood.\n\nMethods:: We established a post-myocardial infarction (MI) HF mouse model via coronary artery ligation, followed by an 8-week exercise regimen at different intensities. Multi-omics sequencing was performed to identify alterations in inflammatory and metabolic pathways.\n\nResults:: Moderate-dose exercise preserved cardiac function and attenuated ventricular remodeling. Metabolomic analysis indicated modulation of lipid metabolism and inflammation via the Apelin pathway. Transcriptomics revealed that the nucleotide-binding oligomerization domain (NOD)-like receptor signaling pathway, which was elevated after MI, was suppressed by moderate-dose exercise. Additionally, Nuclear factor erythroid 2-related factor 2 (Nrf2)—a key transcription factor regulating antioxidant and anti-inflammatory responses—was upregulated in the moderate-exercise group.\n\nConclusions:: Moderate-dose exercise protects against HF in mice by regulating lipid metabolism and inflammatory pathways. These findings support the standardization of exercise therapy for secondary prevention of cardiovascular disease.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cardiology, Life Science Research Center, The First Affiliated Hospital of Xinxiang Medical University, 453100 Xinxiang, Henan, China",
    "Department of Internal Medicine, Henan Yongcheng People’s Hospital, 476600 Yongcheng, Henan, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Dongli Gao",
      "orcid": "0009-0002-2157-5500"
    },
    {
      "affs": [
        1
      ],
      "name": "Maoshuai Zhang",
      "orcid": "0009-0003-5088-3585"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuanhao Li",
      "orcid": "0009-0006-0052-5677"
    },
    {
      "affs": [
        0
      ],
      "name": "Xuefei Liang",
      "orcid": "0009-0004-8168-7373"
    },
    {
      "affs": [
        0
      ],
      "name": "Yue Dong",
      "orcid": "0009-0006-2820-7806"
    },
    {
      "affs": [
        0
      ],
      "name": "Xulei Duan",
      "orcid": "0009-0006-4388-9796"
    },
    {
      "affs": [
        0
      ],
      "name": "Niannian Ding",
      "orcid": "0009-0003-6917-8747"
    },
    {
      "affs": [
        0
      ],
      "name": "Libo Wang",
      "orcid": "0009-0006-2363-6476"
    },
    {
      "affs": [
        0
      ],
      "name": "Xuehui Wang",
      "orcid": "0009-0006-0675-8367"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ayxjqvb3ktmvv.bib",
  "cited_by": 0,
  "doi": "10.31083/rcm51174",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13732661/",
  "id": "ayxjqvb3ktmvv",
  "issns": [
    "1530-6550",
    "2153-8174"
  ],
  "landing_url": "https://doi.org/10.31083/rcm51174",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2705|Cardiac Fibrosis and Remodeling"
    ]
  ],
  "openalex": "W7225261868",
  "pdf_url": "https://storage.imrpress.com/IMR/2112375717048066000/application/2153-8174-27-10-51174.pdf",
  "pmcid": "PMC13732661",
  "pmid": "42985150",
  "published": "2026-10-20",
  "publisher": "IMR Press",
  "ris": "https://research.draconitic.com/paper/ayxjqvb3ktmvv.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:22:36Z",
      "native_id": "PMC13732661",
      "source": "pmc",
      "url": "https://doi.org/10.31083/rcm51174"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiac Fibrosis and Remodeling",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Moderate-Dose Exercise Protects Against Heart Failure via Apelin/NLRP3 Mediated Inflammation",
  "title_text": "Moderate-Dose Exercise Protects Against Heart Failure via Apelin/NLRP3 Mediated Inflammation",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:22:36Z",
  "url": "https://research.draconitic.com/paper/ayxjqvb3ktmvv",
  "venue": "Reviews in Cardiovascular Medicine",
  "versions": []
}