{
  "abstract": "Glucagon-like peptide-1 (GLP-1) is well-known for its biological functions in glucose homeostasis which aligns closely with the antidiabetic function of whole grain foods (WGFs). Although postprandial GLP-1 responses to WGF have been extensively studied, the influence of cell wall-formed dietary fiber (CW-DF), as the main functional component of WGFs, on the GLP-1 response remains poorly understood. Here, Tartary buckwheat flour fractions with different particle sizes (small particle size (SF: 0.2 mm), middle particle size (MF: 0.6 mm), and large particle size (BF: 0.9 mm)), reflecting different degrees of cell wall integrity, were used to investigate how particle size modulates GLP-1 secretion. The in vivo mouse study showed that intact endosperm cells from Tartary buckwheat grains significantly increased the postprandial GLP-1 response. Further study demonstrated that only the hydrolysate from BF augmented GLP-1 secretion from enteroendocrine STC-1 L-cells, which is all positively correlated with the selectively enriched phytochemicals in BF particles (ononin, ginkgolide C, pristimerin, and pentadecanoic acid). Significant correlations between particle size, phytochemical profiles and GLP-1 release demonstrated that the integrity of CW-DF is essential to the nutritional properties of WGFs. Molecular docking simulations suggested putative interactions between phytochemicals and bitter taste receptors in GLP-1 secretion. Thus, cell wall integrity is a pivotal regulator of the health benefits of WGFs, offering a mechanistic rationale for minimal processing to harness the health benefits of WGFs through targeted endogenous GLP-1 production.",
  "abstract_shown": true,
  "affiliations": [
    "State Key Laboratory of Food Science and Resources, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Menglin Jiang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yao Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Genyi Zhang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ayya1gedv1g4j.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27219470",
  "fulltext_url": null,
  "id": "ayya1gedv1g4j",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://www.mdpi.com/1422-0067/27/21/9470",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2916|Food composition and properties"
    ]
  ],
  "openalex": "W7223962570",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-23",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/ayya1gedv1g4j.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:57Z",
      "native_id": "10.3390/ijms27219470",
      "source": "crossref",
      "url": "https://www.mdpi.com/1422-0067/27/21/9470"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "issn:1422-0067",
      "subfield": "general"
    }
  ],
  "title": "Cell Wall-Formed Dietary Fiber in Tartary Buckwheat Governs Selective Enrichment of Phytochemicals to Enhanced Postprandial GLP-1 Response",
  "title_text": "Cell Wall-Formed Dietary Fiber in Tartary Buckwheat Governs Selective Enrichment of Phytochemicals to Enhanced Postprandial GLP-1 Response",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:57Z",
  "url": "https://research.draconitic.com/paper/ayya1gedv1g4j",
  "venue": "International Journal of Molecular Sciences",
  "versions": []
}