{
  "abstract": "BACKGROUND Primary pelvic schwannomas are rare and often misdiagnosed due to non-specific imaging features. Accurate preoperative evaluation remains a challenge. The clinical utility of contrast-enhanced ultrasound (CEUS) combined with time-intensity curve (TIC) analysis and targeted biopsy was evaluated for the preoperative diagnosis and management of a pelvic schwannoma. CASE REPORT A 66-year-old man presented with dysuria and lumbago. Imaging revealed a large, mixed cystic-solid pelvic mass. Conventional ultrasound demonstrated a predominantly cystic-solid lesion with limited Doppler flow, whereas CEUS showed progressive dendritic enhancement of the viable solid component from the periphery toward the center, with non-enhancement of cystic or necrotic areas. TIC analysis demonstrated a distinctive \"equal-in and slow-out\" perfusion pattern, supported by quantitative parameters (rise time, time to peak, fall time, and washout area under the curve). Based on these perfusion characteristics, ultrasound-guided biopsy was directed toward hyperenhanced viable regions while avoiding necrotic zones, thereby improving tissue sampling accuracy. Immunohistochemistry confirmed S-100 and SOX-10 positivity, establishing a definitive diagnosis. Complete surgical resection with bladder defect repair was performed. Postoperatively, urinary function recovered, and no recurrent urinary or pelvic symptoms were reported during outpatient follow-up. CONCLUSIONS Quantitative CEUS-TIC analysis combined with targeted biopsy provides an effective preoperative diagnostic strategy for pelvic schwannomas. The observed CEUS-TIC perfusion pattern may correspond to the heterogeneous microvascular distribution of Antoni A and Antoni B regions; however, this hypothesis requires validation in future imaging-pathology correlation studies.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Ultrasound, Yichang Central People's Hospital, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jinzhe Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Li Wei"
    },
    {
      "affs": [
        0
      ],
      "name": "Yufei Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/azcs8xgzsk1ss.bib",
  "cited_by": 0,
  "doi": "10.12659/ajcr.953317",
  "fulltext_url": "https://europepmc.org/articles/PMC13693437",
  "id": "azcs8xgzsk1ss",
  "issns": [
    "1941-5923"
  ],
  "landing_url": "https://europepmc.org/article/MED/42894353",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2728|Neurofibromatosis and Schwannoma Cases"
    ]
  ],
  "openalex": "W7211889177",
  "pdf_url": "https://europepmc.org/articles/PMC13693437?pdf=render",
  "pmcid": "PMC13693437",
  "pmid": "42894353",
  "published": "2026-10-19",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/azcs8xgzsk1ss.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:32Z",
      "native_id": "MED:42894353",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42894353"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Neurofibromatosis and Schwannoma Cases",
      "subfield": "neurology"
    }
  ],
  "title": "Contrast-Enhanced Ultrasound Combined With Biopsy for the Preoperative Diagnosis of a Rare Pelvic Schwannoma: A Case Report.",
  "title_text": "Contrast-Enhanced Ultrasound Combined With Biopsy for the Preoperative Diagnosis of a Rare Pelvic Schwannoma: A Case Report.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:32Z",
  "url": "https://research.draconitic.com/paper/azcs8xgzsk1ss",
  "venue": "The American journal of case reports",
  "versions": []
}