{
  "abstract": "Phagocytosis is a cornerstone of the immune defence, allowing cells to eliminate pathogens through both opsonic and non-opsonic pathways. In protozoa such as Entamoeba histolytica, non-opsonic phagocytosis is not only central to survival but also to its ability to cause disease, with its life cycle closely intertwined with the intestinal microbiota, which supplies bacteria and their metabolic byproducts to support trophozoite growth. Yet, despite its significance, the molecular basis of how E. histolytica recognises and engulfs bacteria remains largely unresolved. This review examines the cell-surface molecules that may mediate bacteria–amoeba interactions and highlights new strategies to uncover their roles, offering fresh insight into the dynamics of non-opsonic phagocytosis.",
  "abstract_shown": true,
  "affiliations": [
    "Institut Pasteur, Université Paris Cité, Biological Image Analysis Unit, Centre National de la Recherche Scientifique UMR3691, Paris, France"
  ],
  "article_type": "Review",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Elisabeth Labruyère"
    },
    {
      "name": "Thomas Treport"
    },
    {
      "name": "Jean-Christophe Olivo-Marin"
    },
    {
      "name": "Nancy Guillen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/azrmgvkfnyd95.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.ppat.1014560",
  "fulltext_url": "https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1014560",
  "id": "azrmgvkfnyd95",
  "issns": [
    "1553-7374",
    "1553-7366"
  ],
  "landing_url": "https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1014560",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "openalex",
      "2725|Amoebic Infections and Treatments"
    ],
    [
      "plos",
      "/Biology and life sciences/Biochemistry/Glycobiology/Glycoproteins"
    ],
    [
      "plos",
      "/Biology and life sciences/Biochemistry/Proteins/Immune system proteins/Immune receptors/Pattern recognition receptors"
    ],
    [
      "plos",
      "/Biology and life sciences/Biochemistry/Proteins/Lectins"
    ],
    [
      "plos",
      "/Biology and life sciences/Cell biology/Cell processes/Phagocytosis"
    ],
    [
      "plos",
      "/Biology and life sciences/Cell biology/Signal transduction/Immune receptors/Pattern recognition receptors"
    ],
    [
      "plos",
      "/Biology and life sciences/Immunology/Immune system proteins/Immune receptors/Pattern recognition receptors"
    ],
    [
      "plos",
      "/Biology and life sciences/Microbiology/Bacteriology/Bacterial physiology/Adhesins"
    ],
    [
      "plos",
      "/Biology and life sciences/Microbiology/Medical microbiology/Microbial pathogens/Bacterial pathogens"
    ],
    [
      "plos",
      "/Biology and life sciences/Microbiology/Microbial physiology/Bacterial physiology/Adhesins"
    ],
    [
      "plos",
      "/Biology and life sciences/Organisms/Bacteria"
    ],
    [
      "plos",
      "/Biology and life sciences/Organisms/Eukaryota/Protozoans/Parasitic protozoans/Entamoeba histolytica"
    ],
    [
      "plos",
      "/Medicine and health sciences/Immunology/Immune system proteins/Immune receptors/Pattern recognition receptors"
    ],
    [
      "plos",
      "/Medicine and health sciences/Pathology and laboratory medicine/Pathogens/Microbial pathogens/Bacterial pathogens"
    ],
    [
      "plos",
      "/Medicine and health sciences/Pathology and laboratory medicine/Pathogens/Virulence factors/Adhesins"
    ]
  ],
  "openalex": "W7213951073",
  "pdf_url": "https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1014560&type=printable",
  "pmcid": null,
  "pmid": "42766630",
  "published": "2026-09-21",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/azrmgvkfnyd95.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:43Z",
      "native_id": "10.1371/journal.ppat.1014560",
      "source": "plos",
      "url": "https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1014560"
    },
    {
      "first_seen": "2026-11-05T12:20:13Z",
      "native_id": "hal-05852508",
      "source": "hal",
      "url": "https://hal.science/hal-05852508v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "plos:cell biology",
      "subfield": "cell-biology"
    },
    {
      "field": "biology",
      "origin": "plos:immunology",
      "subfield": "immunology"
    },
    {
      "field": "biology",
      "origin": "plos:microbiology",
      "subfield": "microbiology"
    }
  ],
  "title": "Exploring glycocalyx components powering the contact between Entamoeba histolytica and bacteria during non-opsonic phagocytosis",
  "title_text": "Exploring glycocalyx components powering the contact between Entamoeba histolytica and bacteria during non-opsonic phagocytosis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:20:44Z",
  "url": "https://research.draconitic.com/paper/azrmgvkfnyd95",
  "venue": "PLOS Pathogens",
  "versions": []
}