{
  "abstract": "Lipid nanoparticles (LNP) are widely used in biomedical applications due to their biocompatibility and safety, yet their translation to plant systems remains limited. Here, we establish a unified strategy integrating antibacterial compound discovery, plant-adapted nanocarrier design, and mechanistic elucidation to combat bacterial plant diseases. A series of thymol-derived quaternary ammonium compounds were synthesized, among which C2 was identified as the lead candidate with potent antibacterial activity (EC50 = 0.78 µg/mL). Upon co-assembly into lipid nanoparticles, C2@LNP exhibited pH-responsive release under infection-associated acidic conditions and achieved a high drug-loading efficiency of 82.41%. This plant-tailored LNP system enhances cuticle penetration and foliar retention, as demonstrated by systematic analyses of leaf deposition, droplet behavior, and microscopic adhesion. Consequently, C2@LNP enabled improved disease control at reduced dosages, with protective and curative efficacies 1.94-fold and 1.56-fold higher than those of free C2, respectively. Interestingly, certain lipid components of the nanocarrier, particularly HSPC, exhibited a preliminary plant growth–promoting potential. Mechanistic studies indicated that the enhanced antibacterial performance arises from suppression of quorum sensing, membrane disruption, and induction of apoptosis-like cell death. Overall, this work establishes a sustainable pesticide delivery paradigm for environmentally friendly crop protection.\n\nGraphical abstract:\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s12951-026-04885-2.",
  "abstract_shown": true,
  "affiliations": [
    "State Key Laboratory of Green Pesticides, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, 550025 China",
    "School of Chemistry and Chemical Engineering, Guizhou University, Guiyang, 550025 China",
    "Guizhou Tea Research Institute, Guizhou Academy of Agricultural Sciences, Guiyang, 550006 China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 11,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Jia-Rui Rao"
    },
    {
      "affs": [
        1
      ],
      "name": "Lei Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhi-Jun Luo"
    },
    {
      "affs": [
        0
      ],
      "name": "Pan Xu"
    },
    {
      "affs": [
        1
      ],
      "name": "Chao-Yu Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Tai-Hong Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jin-Hong Hu"
    },
    {
      "affs": [
        0
      ],
      "name": "Li-Wei Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhi-Bing Wu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiang Zhou"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Song Yang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/azxgtsfzqe25d.bib",
  "cited_by": 2,
  "doi": "10.1186/s12951-026-04885-2",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13729601/",
  "id": "azxgtsfzqe25d",
  "issns": [
    "1477-3155"
  ],
  "landing_url": "https://doi.org/10.1186/s12951-026-04885-2",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "1102|Polymer-Based Agricultural Enhancements"
    ]
  ],
  "openalex": "W7196923462",
  "pdf_url": null,
  "pmcid": "PMC13729601",
  "pmid": "42977950",
  "published": "2026-08-07",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/azxgtsfzqe25d.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:22:19Z",
      "native_id": "PMC13729601",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12951-026-04885-2"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1102|Polymer-Based Agricultural Enhancements",
      "subfield": "plant-biology"
    }
  ],
  "title": "Constructing co-assembly derived smart lipid nanoparticles for enhanced antimicrobial potency with plant growth-promoting potential",
  "title_text": "Constructing co-assembly derived smart lipid nanoparticles for enhanced antimicrobial potency with plant growth-promoting potential",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:19Z",
  "url": "https://research.draconitic.com/paper/azxgtsfzqe25d",
  "venue": "Journal of Nanobiotechnology",
  "versions": []
}