{ "abstract": "INTRODUCTION: Real‐world data on lecanemab's efficacy and the longitudinal dynamics of plasma biomarkers are scarce in Chinese patients with Alzheimer's disease (AD).\n\nMETHODS: In this multicenter cohort study, 181 AD patients received biweekly lecanemab. Disease‐stage‐specific Clinical Dementia Rating–Sum of Boxes meaningful within‐patient change defined response at Months 3, 6, and 12. We used penalized models, receiver operating characteristic analysis, attrition comparisons, and exploratory Month 3 plasma biomarker analysis.\n\nRESULTS: Cognitive response emerged at Month 6 and intensified by Month 12, largely restricted to mild cognitive impairment and mild dementia due to AD. Repeated five‐fold cross‐validated areas under the curve across the follow‐up timepoints were 0.560, 0.747, and 0.773, with apolipoprotein E ε4 positivity and more severe cognitive impairment linked to lower response odds. Plasma phosphorylated tau 217 (p‐tau217) and amyloid beta (Aβ) 42/40 altered as early as Month 3. Month 3 Aβ42/40 showed modest exploratory discrimination. The incidence of amyloid‐related imaging abnormalities was 7.2%, all asymptomatic.\n\nDISCUSSION: Lecanemab is effective and safe in AD over 6 to 12 months. Early biomarker changes (p‐tau217, Aβ42/40) precede clinical improvement, serving as scalable response indicators.", "abstract_shown": true, "affiliations": [ "Department of Neurology Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University Nanjing China", "Jiangsu Stroke Association Nanjing Jiangsu China", "Department of Biostatistics School of Public Health Nanjing Medical University Nanjing Jiangsu China", "Department of Geriatrics Nanjing Brain Hospital affiliated to Nanjing Medical University Nanjing China", "Department of Neurology Taizhou School of Clinical Medicine The Affiliated Taizhou People's Hospital of Nanjing Medical University Nanjing Medical University Taizhou Jiangsu China", "Department of Neurology Nanjing First Hospital Nanjing Medical University Nanjing China", "Department of Neurology Affiliated Hospital of Jiangnan University Wuxi Jiangsu China", "Department of Neurology The Affiliated Suzhou Hospital of Nanjing University Medical School Suzhou China", "Department of Neurology Xuzhou Central Hospital Jiangsu China", "Department of Neurology BENQ Medical Center Nanjing China", "Department of Neurology Geriatric Hospital of Nanjing Medical University Nanjing China", "Department of Neurology Affiliated Hospital of Nantong University Nantong China", "Department of Neurology Affiliated ZhongDa Hospital, School of Medicine, Southeast University Nanjing Jiangsu China", "Department of Neurology Affiliated Subei People's Hospital Yangzhou University Yangzhou China", "Department of Neurology The Affiliated Hospital of Yangzhou University Yangzhou China", "Department of Neurology The Affiliated Hospital of Jiangsu University Zhenjiang Jiangsu China", "Department of Neurology The Third Affiliated Hospital of Soochow University Changzhou Jiangsu China", "Department of Neurology The Second Affiliated Hospital of Soochow University Suzhou China", "Department of Neurology The Fourth Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu China", "Department of Neurology The First Affiliated Hospital of Soochow University Suzhou Medical College of Soochow University Suzhou China", "Department of Neurology Nanjing First Hospital Nanjing Medical University Nanjing Jiangsu China", "Department of Neurology The Taixing People's Hospital Taixing China", "Department of Neurology Affiliated Hospital of Xuzhou Medical University Xuzhou Jiangsu China", "State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing University Nanjing China", "Center for Central Nervous Diseases and Neuroscience in Nanjing Drum Tower Hospital Nanjing China", "Nanjing Key Laboratory for Cardiovascular Information and Health Engineering Medicine Nanjing China", "Nanjing Neurology Clinical Medical Centre, and Centre for Central Nervous Disease and Neuroscience Nanjing China" ], "article_type": "research article", "arxiv": null, "author_total": 34, "authors": [ { "affs": [ 0, 1 ], "name": "Limoran Tang" }, { "affs": [ 2 ], "name": "Xicheng Chen" }, { "affs": [ 3 ], "name": "Li Zhang" }, { "affs": [ 4 ], "name": "Lin Fan" }, { "affs": [ 5 ], "name": "Nihong Chen" }, { "affs": [ 6 ], "name": "Chaosheng Li" }, { "affs": [ 7 ], "name": "Zenglin Cai" }, { "affs": [ 8 ], "name": "Guofang Chen" }, { "affs": [ 0 ], "name": "Haifeng Chen" }, { "affs": [ 9 ], "name": "Min Ye" }, { "affs": [ 10 ], "name": "Huifen Zheng" }, { "affs": [ 0 ], "name": "Qi Li" }, { "affs": [ 0 ], "name": "Zhihong Ke" }, { "affs": [ 0 ], "name": "Zheqi Hu" }, { "affs": [ 11 ], "name": "Maohong Cao" }, { "affs": [ 0 ], "name": "Dan Yang" }, { "affs": [ 0 ], "name": "Shuai Xu" }, { "affs": [ 12 ], "name": "Chunming Xie" }, { "affs": [ 13 ], "name": "Xiaobo Li" }, { "affs": [ 14 ], "name": "Xiaotian Xu" }, { "affs": [ 15 ], "name": "Ming Yu" }, { "affs": [ 16 ], "name": "Xuegan Lian" }, { "affs": [ 17 ], "name": "Hua Hu" }, { "affs": [ 18 ], "name": "Hongfei Li" }, { "affs": [ 19 ], "name": "Xiuying Cai" }, { "affs": [ 20 ], "name": "Hong Chen" }, { "affs": [ 21 ], "name": "Wu Xu" }, { "affs": [ 22 ], "name": "Guiyun Cui" }, { "affs": [ 2 ], "name": "Yang Zhao" }, { "affs": [ 3 ], "name": "Jingde Dong" }, { "affs": [ 6 ], "name": "Lili Zhang" }, { "affs": [ 0, 1, 23, 24, 25, 26 ], "name": "Xiaolei Zhu" }, { "affs": [ 0 ], "name": "Hui Zhao" }, { "affs": [ 0, 1, 23, 24, 25, 26 ], "name": "Yun Xu" } ], "bibtex": "https://research.draconitic.com/paper/azz8eyjwjj2g9.bib", "cited_by": 0, "doi": "10.1002/alz.71936", "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710672/", "id": "azz8eyjwjj2g9", "issns": [ "1552-5260", "1552-5279" ], "landing_url": "https://doi.org/10.1002/alz.71936", "language": "en", "licence": "CC-BY-4.0", "licence_label": "CC BY 4.0", "licence_source": "article", "licence_url": "https://creativecommons.org/licenses/by/4.0/", "metadata_licence": null, "native_subjects": [ [ "heading", "Research Article" ], [ "openalex", "2737|Alzheimer's disease research and treatments" ] ], "openalex": "W7223991842", "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.71936", "pmcid": "PMC13710672", "pmid": "42934846", "published": "2026-10-26", "publisher": "Wiley", "ris": "https://research.draconitic.com/paper/azz8eyjwjj2g9.ris", "sources": [ { "first_seen": "2026-10-31T12:21:35Z", "native_id": "PMC13710672", "source": "pmc", "url": "https://doi.org/10.1002/alz.71936" } ], "subjects": [ { "field": "medicine", "origin": "openalex:2737|Alzheimer's disease research and treatments", "subfield": "physiology" } ], "title": "Real‐world clinical, biomarker, and imaging outcomes of lecanemab in Alzheimer's disease: a multicenter longitudinal cohort study in Jiangsu, China", "title_text": "Real‐world clinical, biomarker, and imaging outcomes of lecanemab in Alzheimer's disease: a multicenter longitudinal cohort study in Jiangsu, China", "type": "peer-reviewed", "updated_at": "2026-10-31T12:21:35Z", "url": "https://research.draconitic.com/paper/azz8eyjwjj2g9", "venue": "Alzheimer's & Dementia", "versions": [] }