{
  "abstract": "Antibodies engage both activating Fc Receptors and the inhibitory receptor Fc{gamma}RIIB. Why macrophages need a dedicated inhibitory receptor rather than simply tuning activating receptor signaling is unclear. Using DNA-based chimeric receptors and in silico modeling, we independently controlled activating and inhibitory Fc Receptors. We found that Fc{gamma}RIIB imposed a time limit on macrophage phagocytosis and ERK signaling. The time limit is due to activating Fc Receptors converting PI(4,5)P2 to PI(3,4,5)P3, which is subsequently converted to PI(3,4)P2 by Fc{gamma}RIIB. This leads to a pulse of active signaling, which is sufficient for phagocytosis of small bacteria-sized targets but not phagocytosis of large targets and TNF secretion. Unlike engaging Fc{gamma}RIIB, reducing activating Fc Receptor signaling decreased initiation of phagocytosis, the speed of PI(3,4,5)P3 generation, and the amplitude of ERK signaling. Our results demonstrate that Fc{gamma}RIIB controls the duration of IgG signaling, while the activating Fc Receptors control sensitivity.",
  "abstract_shown": true,
  "affiliations": [
    "UCSB"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "A. Bond"
    },
    {
      "name": "E. T. Snyder"
    },
    {
      "name": "A. Manion"
    },
    {
      "name": "C. Hardy"
    },
    {
      "name": "K. Kieu"
    },
    {
      "name": "M. Z. Wilson"
    },
    {
      "name": "E. A. Yeung"
    },
    {
      "affs": [
        0
      ],
      "name": "M. A. Morrissey"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b08sw9ap1h1dy.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.21.753242",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.21.753242v1.full",
  "id": "b08sw9ap1h1dy",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.21.753242v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "immunology"
    ],
    [
      "openalex",
      "2741|Monoclonal and Polyclonal Antibodies Research"
    ]
  ],
  "openalex": "W7214578513",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.21.753242v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-21",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/b08sw9ap1h1dy.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:24:44Z",
      "native_id": "10.64898/2026.09.21.753242",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.21.753242v3"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:immunology",
      "subfield": "immunology"
    }
  ],
  "title": "Inhibitory Fc Receptor sets a time limit on macrophage response to IgG",
  "title_text": "Inhibitory Fc Receptor sets a time limit on macrophage response to IgG",
  "type": "preprint",
  "updated_at": "2026-10-30T12:25:49Z",
  "url": "https://research.draconitic.com/paper/b08sw9ap1h1dy",
  "venue": "bioRxiv",
  "versions": []
}