{
  "abstract": "PURPOSE: This study aimed to compare the safety and efficacy of two resorbable microparticles in a porcine kidney model, focusing on recanalization and tissue injury outcomes over a 7-day follow-up period.\n\nMETHODS: This exploratory proof-of-concept study included 10 pigs, each undergoing embolization of the upper polar arteries in both kidneys, resulting in 20 treated kidneys (10 per group). Angiographic evaluations were performed on all 20 treated kidneys (10 per group) across the 10 animals at immediate, 2-hour, 1-day, and 7-day post-embolization time points. Histopathologic evaluations were performed on 5 animals per group (5 kidneys per group). The primary endpoint was complete angiographic recanalization at 7 days. Secondary endpoints included early recanalization at 2 hours and 1 day and histopathologic tissue injury. In Group A, the right upper polar artery was embolized with spherical gelatin microparticles (Nexsphere-F®), whereas in Group B, the left upper polar artery was embolized with irregular microparticles (KIPZA®). Approximately 5–10 mL of microparticle suspension was injected per kidney; the mean embolization time per kidney was 30 ± 5 minutes.\n\nRESULTS: At 2 hours post-embolization, complete recanalization was observed in all Nexsphere-F kidneys and in 9 of 10 KIPZA kidneys; 1 KIPZA kidney showed partial recanalization. Full recanalization was observed in all kidneys by day 7. Histopathologic evaluation (5 kidneys per group) revealed no residual emboli or parenchymal infarction in Group A. In Group B, minimal microparticle residue and focal infarction (mean infarcted area 2.78% ± 1.33%) were observed, along with endothelial proliferation in arcuate and interlobular arteries.\n\nCONCLUSION: In this exploratory pilot study, embolization with both Nexsphere-F and KIPZA microparticles resulted in early recanalization and minimal tissue injury. These proof-of-concept findings suggest that both microparticles may be suitable for temporary embolization when organ preservation is paramount, although larger powered studies with disease models and longer follow-up are needed.\n\nCLINICAL SIGNIFICANCE: These preliminary data support the potential of resorbable microparticles for temporary embolization, emphasizing their use in scenarios requiring parenchymal preservation and underscoring the need for further research.",
  "abstract_shown": true,
  "affiliations": [
    "Seoul National University Bundang Hospital, Department of Radiology, Seongnam, Republic of Korea",
    "Jeonbuk National University Faculty of Medicine, Department of Radiology, Jeonju, Republic of Korea",
    "Research Institute of Clinical Medicine of Jeonbuk National University, Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Republic of Korea",
    "Seoul Metropolitan Government, Seoul National University Boramae Medical Center, Department of Radiology, Seoul, Republic of Korea",
    "Seoul National University Bundang Hospital, Department of Plastic and Reconstructive Surgery, Seongnam, South Korea",
    "Seoul National University College of Medicine, Department of Radiology, Seoul, Republic of Korea"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Won Seok Choi",
      "orcid": "0000-0001-9371-873X"
    },
    {
      "affs": [
        0
      ],
      "name": "Kun Yung Kim",
      "orcid": "0000-0002-2018-8130"
    },
    {
      "affs": [
        0
      ],
      "name": "Chong-ho Lee",
      "orcid": "0000-0003-4021-0240"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Young-Min Han",
      "orcid": "0000-0002-3624-6809"
    },
    {
      "affs": [
        3
      ],
      "name": "Minuk Kim",
      "orcid": "0000-0003-0564-5724"
    },
    {
      "affs": [
        4
      ],
      "name": "Sung-hwan Yoon",
      "orcid": "0000-0002-6131-851X"
    },
    {
      "affs": [
        0,
        5
      ],
      "name": "Chang Jin Yoon",
      "orcid": "0000-0002-7660-0489"
    },
    {
      "affs": [
        0,
        5
      ],
      "name": "Jae Hwan Lee",
      "orcid": "0000-0001-6513-3224"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b0bhymxfk7my4.bib",
  "cited_by": 0,
  "doi": "10.4274/dir.2026.263960",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13725028/",
  "id": "b0bhymxfk7my4",
  "issns": [
    "1305-3825",
    "1305-3612"
  ],
  "landing_url": "https://doi.org/10.4274/dir.2026.263960",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Interventional Radiology - Original Article"
    ],
    [
      "openalex",
      "2740|Renal and Vascular Pathologies"
    ]
  ],
  "openalex": "W7155049970",
  "pdf_url": "https://dirjournal.org/pdf/beb8919b-f013-4ea1-b1c8-40332e840fe1/articles/dir.2026.263960/DIR-2026.3960.pdf",
  "pmcid": "PMC13725028",
  "pmid": "42011985",
  "published": "2026-11-02",
  "publisher": "Turkish Society of Radiology",
  "ris": "https://research.draconitic.com/paper/b0bhymxfk7my4.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:23:30Z",
      "native_id": "PMC13725028",
      "source": "pmc",
      "url": "https://doi.org/10.4274/dir.2026.263960"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Renal and Vascular Pathologies",
      "subfield": "general"
    }
  ],
  "title": "Comparative evaluation of two resorbable microparticles in a porcine kidney model: angiographic and pathologic outcomes",
  "title_text": "Comparative evaluation of two resorbable microparticles in a porcine kidney model: angiographic and pathologic outcomes",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:23Z",
  "url": "https://research.draconitic.com/paper/b0bhymxfk7my4",
  "venue": "Diagnostic and Interventional Radiology",
  "versions": []
}