{
  "abstract": "Follicular lymphoma commonly transforms into diffuse large B-cell lymphoma; however, transdifferentiation into histiocytic/dendritic neoplasms is exceptionally rare. We describe an older male with follicular lymphoma that transformed into high-grade B-cell lymphoma with MYC, BCL2 and BCL6 rearrangements, followed by development of a malignant histiocytic neoplasm with dendritic differentiation involving the liver. Shared molecular findings supported transdifferentiation from the original lymphoma clone. While the malignant histiocytic neoplasm showed a complete response to imatinib, the clinical course was complicated by relapsed high-grade B-cell lymphoma and the patient eventually succumbed to infectious complications.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Internal Medicine, The University of Kansas Medical Center, Kansas City, Kansas, USA",
    "Department of Pathology and Laboratory Medicine, The University of Kansas Medical Center, Kansas City, Kansas, USA",
    "Division of Hematologic Malignancies and Cellular Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas, USA"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Chao Wu",
      "orcid": "0009-0003-7939-593X"
    },
    {
      "affs": [
        1
      ],
      "name": "Wei Cui"
    },
    {
      "affs": [
        2
      ],
      "name": "Aung M Tun",
      "orcid": "0000-0002-5245-2354"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b0hzyeh82tyx3.bib",
  "cited_by": 0,
  "doi": "10.1136/bcr-2026-273164",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13723747/",
  "id": "b0hzyeh82tyx3",
  "issns": [
    "1757-790X"
  ],
  "landing_url": "https://doi.org/10.1136/bcr-2026-273164",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Case Report"
    ],
    [
      "heading",
      "Haematology"
    ],
    [
      "openalex",
      "2734|Lymphoma Diagnosis and Treatment"
    ]
  ],
  "openalex": "W7224863489",
  "pdf_url": "https://casereports.bmj.com/content/bmjcr/19/10/e273164.full.pdf",
  "pmcid": "PMC13723747",
  "pmid": "42963063",
  "published": "2026-10-30",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/b0hzyeh82tyx3.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:22:19Z",
      "native_id": "PMC13723747",
      "source": "pmc",
      "url": "https://doi.org/10.1136/bcr-2026-273164"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2734|Lymphoma Diagnosis and Treatment",
      "subfield": "general"
    }
  ],
  "title": "Malignant histiocytic neoplasm with dendritic differentiation via transdifferentiation of B-cell lymphoma",
  "title_text": "Malignant histiocytic neoplasm with dendritic differentiation via transdifferentiation of B-cell lymphoma",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:20:30Z",
  "url": "https://research.draconitic.com/paper/b0hzyeh82tyx3",
  "venue": "BMJ Case Reports",
  "versions": []
}