{
  "abstract": "Background: This study aimed to evaluate the effect of methylprednisolone as adjunctive treatment to endovascular therapy (EVT) in patients with and without diabetes, as well as in patients with and without admission hyperglycemia.\n\nMethods: This study was a secondary analysis of the MARVEL trial. The primary outcome was the ordinal modified Rankin Scale (mRS) score at 90 days. Secondary outcomes included mRS score of 0-3, 0-2, 0–1 at 90 days. Safety outcomes included mortality within 90 days, symptomatic intracranial hemorrhage (sICH) and any ICH within 48 hours.\n\nResults: Among 1,678 patients from the MARVEL trial, 321 had history of diabetes. In patients with diabetes, methylprednisolone was not associated with improved 90-day mRS [common odds radio (cOR), 1.07 (0.81-1.40), P = 0.640] but was associated with more any ICH within 48 hours [OR, 1.63 (1.17-2.26), P = 0.004]. In patients without diabetes, methylprednisolone was associated with better 90-day mRS [cOR, 1.16 (1.02-1.33), P = 0.026] and lower 90-day mortality [OR, 0.74 (0.62-0.88), P = 0.001]. A significant treatment-by-diabetes-history interaction was observed only for any ICH within 48 hours (P for interaction = 0.036). Among 1,470 patients stratified by admission hyperglycemia, methylprednisolone was not associated with improved 90-day mRS in either subgroup.\n\nConclusion: The glycemia status-by-treatment interaction was not significant. A benefit trend was observed with adjunctive methylprednisolone in patients without diabetes. However, adjunctive use of methylprednisolone in patients with diabetes may be with a higher risk of any intracranial hemorrhage. Admission hyperglycemia status did not significantly modify the effectiveness or safety of methylprednisolone. These findings warrant validation in further studies.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurosurgery, The People's Hospital of Qiandongnan Miao and Dong Autonomous Prefecture",
    "Department of Encephalopathy, Hubei Provincial Hospital of Traditional Chinese Medicine",
    "Hubei Key Laboratory of theory and application research of liver and kidney in traditional Chinese medicine, Affiliated Hospital of Hubei University of Chinese Medicine",
    "Hubei Shizhen Laboratory",
    "Hubei Province Academy of Traditional Chinese Medicine",
    "Department of Neurology, The Second Hospital & Clinical Medical School, Lanzhou University",
    "Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University)",
    "Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University",
    "Department of Neurology, The 908th Hospital of Chinese People’s Liberation Army Joint Logistic Support Force",
    "Department of Neurology, Renhuai People’s Hospital",
    "The First Clinical Medical School, Hubei University of Chinese Medicine"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 20,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Lei Zhang"
    },
    {
      "affs": [
        1,
        2,
        3,
        4
      ],
      "name": "Beibei Zhang"
    },
    {
      "affs": [
        5
      ],
      "name": "Lingyu Zhang"
    },
    {
      "affs": [
        6
      ],
      "name": "Kaiyuan Feng"
    },
    {
      "affs": [
        7
      ],
      "name": "Linyu Li"
    },
    {
      "affs": [
        6,
        8
      ],
      "name": "Haoxuan Zhu"
    },
    {
      "affs": [
        6
      ],
      "name": "Xu Xu"
    },
    {
      "affs": [
        6
      ],
      "name": "Jinfu Ma"
    },
    {
      "affs": [
        9
      ],
      "name": "Sheng Zhou"
    },
    {
      "affs": [
        6
      ],
      "name": "Zhixi Wang"
    },
    {
      "affs": [
        6
      ],
      "name": "Jiayu Li"
    },
    {
      "affs": [
        6
      ],
      "name": "Qiuyi Yang"
    },
    {
      "affs": [
        6
      ],
      "name": "Yian Chen"
    },
    {
      "affs": [
        6
      ],
      "name": "Mingyang Chen"
    },
    {
      "affs": [
        6
      ],
      "name": "Yihui Yang"
    },
    {
      "affs": [
        6
      ],
      "name": "Yuhan Fan"
    },
    {
      "affs": [
        6
      ],
      "name": "Junjie Yuan"
    },
    {
      "affs": [
        7
      ],
      "name": "Jiaxing Song"
    },
    {
      "affs": [
        6
      ],
      "name": "Gaoming Li"
    },
    {
      "affs": [
        10
      ],
      "name": "Mingrui Zhou"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b0s1abm083ve0.bib",
  "cited_by": 0,
  "doi": "10.3389/fendo.2026.1932813",
  "fulltext_url": "https://europepmc.org/articles/PMC13686846",
  "id": "b0s1abm083ve0",
  "issns": [
    "1664-2392"
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  "landing_url": "https://www.frontiersin.org/articles/10.3389/fendo.2026.1932813/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
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      "2713|Acute Ischemic Stroke Management"
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  "pdf_url": "https://europepmc.org/articles/PMC13686846?pdf=render",
  "pmcid": "PMC13686846",
  "pmid": "42922831",
  "published": "2026-10-08",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/b0s1abm083ve0.ris",
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      "origin": "openalex:2713|Acute Ischemic Stroke Management",
      "subfield": "epidemiology-public-health"
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  "title": "Outcomes of methylprednisolone as an adjunct to endovascular therapy in patients with diabetes and admission hyperglycemia",
  "title_text": "Outcomes of methylprednisolone as an adjunct to endovascular therapy in patients with diabetes and admission hyperglycemia",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:36Z",
  "url": "https://research.draconitic.com/paper/b0s1abm083ve0",
  "venue": "Frontiers in Endocrinology",
  "versions": []
}