{
  "abstract": "Faithful genome reactivation after mitosis is essential for cell identity, yet the mechanisms driving global postmitotic transcription remain unclear. Here, we show that the MYC oncogene and its obligate partner MAX drive a postmitotic hypertranscriptional state in mouse embryonic stem cells. Cell cycle–resolved single-cell RNA-seq in inducible Max −/− cells reveals that early G1 hypertranscription is strongly impaired without MAX. Mechanistically, MAX remains bound to thousands of promoters during mitosis, while MYC is largely excluded. Using high-temporal-resolution profiling, pharmacological inhibition of MYC/MAX, and acute MAX degradation at mitotic exit, we demonstrate that MAX mitotic binding triggers rapid MYC recruitment and transcriptional amplification of TBP-bound promoters by enhancing RNA polymerase II occupancy and efficient initiation and elongation. These findings redefine MYC/MAX as master regulators of gene regulatory inheritance across mitosis.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Developmental and Stem Cell Biology, Institut Pasteur, Université Paris Cité, CNRS UMR3738, Epigenomics, Proliferation, and the Identity of Cells Unit, Paris 75015, France",
    "Equipe Labélisée Ligue Contre le Cancer, Paris 75015, France",
    "Department of Microbiology, Institut Pasteur, Université Paris Cité, CNRS UMR 6047, Biologie des Bactéries Intracellulaires, Paris 75015, France",
    "College Doctoral, Sorbonne Université, Paris 75006, France",
    "Department of Developmental and Stem Cell Biology, Institut Pasteur, Université Paris Cité, CNRS UMR3738, Macrophages and Endothelial Cells Unit, Paris 75015, France",
    "Université Paris Cité, CNRS, Institut Jacques Monod, Paris 75013, France",
    "Centre de Ressources et Recherches Technologiques (UTechS-PBI, C2RT), Institut Pasteur, Université Paris Cité, CNRS UMR3691, Photonic Bio-Imaging, Paris 75015, France"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Inma Gonzalez"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Lieng Taing"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Almira Chervova"
    },
    {
      "affs": [
        2
      ],
      "name": "Pedro Escoll"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Luis Altamirano-Pacheco"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Alina Sommer"
    },
    {
      "affs": [
        5
      ],
      "name": "Teresa Urli"
    },
    {
      "affs": [
        5
      ],
      "name": "Maxim V.C. Greenberg",
      "orcid": "0000-0001-9935-8763"
    },
    {
      "affs": [
        5
      ],
      "name": "Véronique Legros"
    },
    {
      "affs": [
        5
      ],
      "name": "Guillaume Chevreux"
    },
    {
      "affs": [
        6
      ],
      "name": "Florian Mueller"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Agnès Dubois"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Pablo Navarro",
      "orcid": "0000-0002-2700-6598"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/b0zb5rhfka32v.bib",
  "cited_by": 0,
  "doi": "10.1101/gad.354072.126",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13726614/",
  "id": "b0zb5rhfka32v",
  "issns": [
    "0890-9369",
    "1549-5477"
  ],
  "landing_url": "https://hal.science/hal-05768909v1",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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    [
      "heading",
      "Research Paper"
    ],
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      "openalex",
      "1312|Genomics and Chromatin Dynamics"
    ]
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  "openalex": "W7196934497",
  "pdf_url": "https://hal.science/hal-05768909/document",
  "pmcid": "PMC13726614",
  "pmid": "42562574",
  "published": "2026-08-06",
  "publisher": "Cold Spring Harbor Laboratory Press",
  "ris": "https://research.draconitic.com/paper/b0zb5rhfka32v.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:43Z",
      "native_id": "hal-05768909",
      "source": "hal",
      "url": "https://hal.science/hal-05768909v1"
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    {
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      "native_id": "PMC13726614",
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      "url": "https://doi.org/10.1101/gad.354072.126"
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  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Genomics and Chromatin Dynamics",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Mitotic MAX bookmarking drives MYC-dependent hypertranscription at TBP-bound promoters",
  "title_text": "Mitotic MAX bookmarking drives MYC-dependent hypertranscription at TBP-bound promoters",
  "type": "preprint",
  "updated_at": "2026-11-06T12:22:31Z",
  "url": "https://research.draconitic.com/paper/b0zb5rhfka32v",
  "venue": "Genes and Development",
  "versions": []
}